Chemistry: analytical and immunological testing – Biological cellular material tested
Reexamination Certificate
2011-08-02
2011-08-02
Bunner, Bridget E (Department: 1647)
Chemistry: analytical and immunological testing
Biological cellular material tested
C436S086000, C436S501000, C435S007100, C435S007920, C514S001000, C514S001100, C530S350000
Reexamination Certificate
active
07989208
ABSTRACT:
The present invention relates to the biomarker TFF-3 that measures γ-secretase mediated Notch processing. TFF-3 has utility in predicting and/or determining in vivo Notch-related toxicity associated with inhibition of Notch processing mediated by γ-secretase. The reagents and methods of the invention can be utilized before, after, or concurrently with, pre-clinical, clinical, and/or post-clinical testing. The reagents and methods of the invention can be used to identify and maintain preferred doses of test compounds and thereby prevent medical complications, such as gastrointestinal cellular damage.
REFERENCES:
patent: WO97/33551 (1997-09-01), None
patent: WO2005/013802 (2005-02-01), None
Verburg et al. Specific responses in rat small intestinal epithelial mRNA expression and protein levels during chemotherapeutic damage and regeneration. J Histochem Cytochem 50: 1525-1536, 2002.
Familari, M. et al., “Trefoil peptides are early markers of gastrointestinal maturation in the rat”, Int. J. Dev. Biol., vol. 42, pp. 783-789 (1998).
Podolsky, D. et al., “Identification of Human Intestinal Trefoil Factor”, The Journal of Biological Chemistry, vol. 268(9), pp. 6694-6702 (1993).
Schonhoff, S. et al., “Minireview: Development and Differentiation of Gut Endocrine Cells”, Endocrinology, vol. 145(6), pp. 2639-2644 (2004).
Shroyer, N. et al., “Gfi1functions downstream ofMath1to control intestinal secretory cell subtype allocation and differentiation”, Genes & Development, vol. 19, pp. 2412-2417 (2005).
Thim, L. “Trefoil peptides: from structure and function”. Cell Mol Life Science, vol. 53, pp. 888-903 (1997).
Barten et al., “Gamma secretase inhibitors for Alzheimer's Disease”, Drugs R D, vol. 7(2), pp. 87-97 (2006).
Durual et al., “Expression of human TFF3 in relation to growth of HT-29 cell subpopulations: involvement of P13-K but not STAT6”, Differentiation, vol. 73, pp. 36-44 (2005).
Nozaki et al., “Regulation and function of trefoil factor family 3 expression in the biliary tree”. Am J Pathol., vol. 165(6), pp. 1907-1920 (2004).
Washizawa et al., “Comparative effects of glucagon-like peptide-2 (GLP-2), Growth Hormone (GH), and keratinocyte growth factor (KGF) on markers of gut adaptation after massive small bowel resection in rats”, JPEN, vol. 28(6), pp. 399-409 (2004).
Blanchard et al., “IL-4 and II-13 up-regulate intestinal trefoil factor expression: requirement for STAT6 and de novo protein synthesis”. J Immunol. vol. 172(6), pp. 3775-3783 (2004.
Xian, et al., “Temporal changes in TFF3 expression and jejunal morphology during methotrexate-induced damage and repair”, Am J Physiol., vol. 277, pp. G785-G795 (1999).
Artavanis-Tsakonas, S. et al., “Notch Signaling: Cell Fate Control and Signal Integration in Development”, Science, vol. 284, pp. 770-776 (1999).
Ausubel, F., Short Protocols in Molecular Biology, Fifth Edition, Wiley publishers (2002).
Barten, D. et al., “Dynamics of β-Amyloid Reductions in Brain, Cerebrospinal Fluid, and Plasma of β-Amyloid Precursor Protein Transgenic Mice Treated with a γ-Secretase Inhibitor”, The J. of Pharmacology and Experimental Therapeutics, vol. 312(2), pp. 635-643 (2005).
Brou, C. et al., “A Novel Proteolytic Cleavage Involved in Notch Signaling: The Role of the Disintegrin-Metalloprotease TACE”, Molecular Cell, vol. 5, pp. 207-216 (2000).
De Strooper, B. et al., “A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain”, Nature, vol. 398, pp. 518-522 (1999).
De Strooper, B., “Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex”, Neuron, vol. 38, pp. 9-12 (2003).
Donoviel, D. et al., “Mice lacking both presenilin genes exhibitearlyembryonic patterning defects”, Genes & Development, vol. 13, pp. 2801-2810 (1999).
Hardy, J. et al., “The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics”, Science, vol. 297, pp. 353-357 (2002).
Herreman, A, et al., “Presenilin 2 deficiency causes a mold pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency”, PNAS, vol. 96(21), pp. 11872-11877 (1999).
Huppert, S. et al., “Embryonic lethality in mice homozygous for a processing-deficient allele of Notch 1”, Nature, vol. 405, pp. 966-970 (2000).
Jarriault, S. et al., “Delta-1 Activation of Notch-1 Signaling Results inHES-1Transactivation”, Molecular and Cellular Biology, vol. 18(12), pp. 7423-7431 (1998).
Jensen, J. et al., “Control of endodermal endocrine development by Hes-1”, Nature Genetics, vol. 24, pp. 36-44 (2000).
Kadesch, T., “Review: Notch Signaling: A Dance of Proteins Changing Partners”, Experimental Cell Research, vol. 260, pp. 1-8 (2000).
Kopan, R. et al., “Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain”, PNAS, vol. 93, pp. 1683-1688 (1996).
Levitan, D. et al., “Effects of SEL-12 presenilin on LIN-12 localization and function inCaenorhabditis elegans”, Development vol. 125(18), pp. 3599-3606 (1998).
Levitan, D. et al., “Facilitation oflin-12-mediated signaling bysel-12, aCaenorhabditis elegans S182Alzheimer's disease gene”, Nature, vol. 377, pp. 351-354 (1995).
Logeat, F. et al., “The Notch1 receptor is cleaved constitutively by a furin-like convertase”, PNAS, vol. 95, pp. 8108-8112 (1998).
Mattson, M., “Pathways towards and away from Alzheimer's disease”, Nature, vol. 430, pp. 631-639 (2004).
Mizutani. T. et al., “Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members”, PNAS, vol. 98(16), pp. 9026-9031 (2001).
Milano, J. et al., “Modulation of Notch Processing by γ-Secretase Inhibitors Causes intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation”, Toxicological Sciences, vol. 82, pp. 341-358 (2004).
Mumm, J. et al., “A Ligand-lnduced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch1”, Molecular Cell, vol. 5, pp. 197-206 (2000).
Oddo, S. et al., “Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction”, Neuron, vol. 39, pp. 409-421 (2003).
Oddo, S. et al., “Aβ Immunotherapy Leads to Clearance of Early, but Not Late, Hyperphosphorylated Tau Aggregates via the Proteasome”, Neuron, vol. 43, pp. 321-332 (2004).
Oddo, S. et al., “Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease”, Neurobiology of Aging, vol. 24, pp. 1063-1070 (2003).
Ohtsuka, T. et al., “Hes1andHes5as Notch effectors in mammalian neuronal differentiation”, The EMBO Journal, vol. 18(8), pp. 2196-2207 (1999).
Pan, D. et al., “Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis”, Cell, vol. 90, pp. 271-280 (1997).
Saxena, M. et al., “Murine Notch Homologs (N1-4) Undergo Presenilin-dependent Proteolysis”, The J. of Biological Chemistry, vol. 276(43), pp. 40268-40273 (2001).
Petit, A. et al., “JLK Isocoumarin Inhibitors: Selective γ-Secretase Inhibitors That Do Not Interfere With Notch Pathway In Vitro or In Vivo”, Journal of Neuroscience Research, vol. 74, pp. 370-377 (2003).
Sambrook, J. et al., Molecular Cloning—A Laboratory Manual, Third Edition, Cold Spring Harbor Laboratory Press (2001).
Schroeter, E. et al., “Notch-1 signalling requires ligand-induced proteolytic release of intrace
Denton Rex
Meredith Jere E.
Bristol--Myers Squibb Company
Bunner Bridget E
Miller Melissa
LandOfFree
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