Gamma secretase inhibitors

Details Gamma secretase inhibitors Gamma secretase inhibitors

2007-08-14

2007-08-14

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C546S001000, C546S018000, C546S148000, C546S186000, C546S192000, C546S236000, C546S339000, C548S542000, C548S952000, C548S950000, C540S604000, C514S212010, C514S345000, C514S418000

Reexamination Certificate

active

10941440

ABSTRACT:
This invention discloses novel gamma secretase inhibitors of the formula:wherein:R1is a substituted aryl or substituted heteroaryl group;R2is an R1group, alkyl, —XC(O)Y, alkylene-XC(O)Y, cycloalkylene-X—C(O)—Y, —CH—X—C(O)—NR3—Y or —CH—X—C(O)—Y, wherein X and Y are as defined herein;each R3and each R3Aare independently H, or alkyl;R11is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer's Disease using one or more compounds of the invention.

REFERENCES:
patent: 2004/0171614 (2004-09-01), Pissarnitski
patent: WO 99/45006 (1999-09-01), None
patent: WO 02/02554 (2002-01-01), None
patent: WO 03/066592 (2003-08-01), None
patent: WO 2005/028440 (2005-03-01), None
International Search Report for PCT/US2004/030191 (CN01538K1) dated Sep. 15, 2004—3 Pages.

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