Gamma secretase inhibitors

Details Gamma secretase inhibitors Gamma secretase inhibitors

2006-10-17

2006-10-17

Raymond, Richard (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S194000, C546S191000, C546S208000, C546S210000, C546S212000, C546S197000, C546S193000, C544S058400, C544S130000, C544S335000, C544S365000, C514S227800, C514S235500, C514S256000, C514S316000, C514S321000, C514S326000

Reexamination Certificate

active

07122675

ABSTRACT:
Novel aryl and heteroaryl sulfonamides are disclosed. The sulfonamides, which are gamma secretase inhibitors, are represented by the formula:wherein Ar1and Ar2independently represent aryl or heteroaryl and Y represents a bond or a —(C(R3)2)1-3group. Also disclosed is a method of inhibiting gamma secretase, and a method of treating Alzheimer's disease using the compounds of formula I.

REFERENCES:
patent: 5646167 (1997-07-01), MacPherson et al.
patent: 2802206 (2001-06-01), None
patent: WO 00/50391 (2000-08-01), None
patent: WO 01/81308 (2001-04-01), None
patent: WO 02/24649 (2001-09-01), None
CAS printout for MacPherson et al. (Chem Abstract 127: 162116.
Hansen, H.,“Multistep Solution-Phase Parallel Synthesis of Spiperone Analogues”, Bioorganic & Medicinal Chemistry Letters, vol. 10, 2000, pp. 2435-2439.

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