Gamma-secretase inhibitors

Details Gamma-secretase inhibitors Gamma-secretase inhibitors

2006-05-23

2006-05-23

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C548S311100, C548S339100, C560S024000

Reexamination Certificate

active

07049296

ABSTRACT:
Urea derivatives of formula I are disclosed: The compounds are inhibitors of γ-secretase, and hence useful in the treatment or prevention of Alzheimer's Disease

REFERENCES:
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patent: 0-554-400 (1997-07-01), None
patent: WO 92/08698 (1992-05-01), None
MM Esiri, SC Biddolph, and CS Morris. Prevalence of alzheimer plaques in AIDS. (1998) J. Neurol. Neurosurg. Psychiatry, 65, 29-33.
WebMD Alzheimer's Disease: treatment overview. Http://my.webmd.com/content/article/71/81399.htm. Accessed Feb. 22, 2005. 2 pages.
ADEAR Alzheimer's Disease Medications fact sheet. NIH Publication 03-3431. Alzheimer's Disease Education & Referral Center. National Institute on Aging, NIH, US Dept HHS. Jul. 2004. 6 pages.
C Ballard, et al. Quetiapine and rivastigmine and cognitive decline in Alzheimer's disease : randomized double blind placebo controlled trial. British Medical Journal. (2005) Feb. 18, 5 pages.
ET Sutton, et al. B-amyloid-induced endothelial necrosis and inhibition of nitric oxide production. Experimental Cell Research (1997) 230, pp. 368-376.
H Steiner et al.: Biochemistry vol. 38, No. 44, 1999, pp. 14600-14605.

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