Gamma-r-glutamoyl derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514333, 514339, 514419, 546147, 546256, 546273, 548201, 548452, 548491, 548533, 562450, 562503, C07D20912, A61K 3140

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active

046788000

ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 and R.sub.6 independently represent hydroxy, C.sub.1 -C.sub.4 -alkoxy, substituted C.sub.1 -C.sub.4 - alkoxy, amino, or substituted amino, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 -alkyl, or C.sub.2 -C.sub.4 -alkenyl, R.sub.3 represents cyclo-C.sub.3 -C.sub.6 -alkyl, phenyl, phenyl substituted by C.sub.1 -C.sub.4 -alkyl, halogen, nitro, or C.sub.1 -C.sub.4 -alkoxy, or cyclo-C.sub.3 -C.sub.6 -alkyl fused with benzene, or wherein R.sub.2 and R.sub.3 are connected and together with the adjacent --CH-group and the adjacent N-atom form a saturated or partially saturated, monocyclic, five- or six-membered heterocyclic group or form a saturated or partially saturated, bicyclic heterocyclic group containing five or six atoms per ring, R.sub.4 represents hydrogen or C.sub.1 -C.sub.4 -alkyl, and R.sub.5 represents an acyl group, are useful as antihypertensive and cardioactive agents. The invention also relates to processes for preparing the compounds of the formula I and to pharmaceutical compositions.

REFERENCES:
patent: 3331828 (1967-07-01), Inamine et al.
patent: 4052511 (1977-10-01), Cushman et al.
patent: 4311705 (1982-01-01), Ondetti et al.
patent: 4329473 (1982-05-01), Almquist et al.
patent: 4374847 (1983-02-01), Gruenfeld
patent: 4396773 (1983-08-01), Kim et al.
patent: 4404206 (1983-09-01), Vincent et al.
patent: 4405787 (1983-09-01), Gaitanopoulos
patent: 4568489 (1986-02-01), Floyd
patent: 4587258 (1986-05-01), Gold et al.
International Application WO83/03828, Published Nov. 10, 1983, 76 pages.
M. Ondetti et al; Peptides-Proc. Fifth Am. Pept. Symposium; 1977; pp. 576-578.
S. Magnan et al; J. Med. Chem.; 25, (1982); pp. 1018-1021.
T. Kasai et al; Acta Chemica Scand.; B 33, (1979); pp. 213-218.
M. Lieflander et al; Z. Physiol. Chem., 320, (1960), pp. 35-57.
N. Tal et al; J. Neurochem.; 1982, pp. 574-576.
N. Gruenfeld et al.; J. Med. Chem.; 26, (1983), pp. 1277-1282.

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