.gamma.-pyrones, .gamma.-pyridones, and .gamma.-thiopyrones, the

Details .gamma.-pyrones, .gamma.-pyridones, and .gamma.-thiopyrones, the .gamma.-pyrones, .gamma.-pyridones, and .gamma.-thiopyrones, the

1995-12-12

1997-07-08

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549417, A61K 3135

Patent

active

056461798

ABSTRACT:
The invention relates to novel .gamma.-pyrones, .gamma.-pyridones and .gamma.-thiopyrones and their use as medicaments against viral diseases, preferably for the treatment of retroviral diseases, comprising compounds of the formula (I), in which R.sub.1 and R.sub.2 stand for hydrogen, a branched-chain or unbranched-chain C.sub.1 to C.sub.26, preferably C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.26 alkenyl or C.sub.1 to C.sub.26 alkinyl group or combinations thereof; R.sub.3 stands for a branched-chain or unbranched-chain C.sub.1 to C.sub.26 alkyl group; and R.sub.4 stands for a C.sub.3 to C.sub.26 cycloalkyl, branched-chain or unbranched-chain alkyl, alkenyl or alkinyl group. The hydrogen atoms of the methylenic group in R.sub.1, R.sub.2 and R.sub.4 may be substituted by O alkyl (C.sub.1 to C.sub.6), O acyl, O aryl, O aralkyl and alkyl (C.sub.1 to C.sub.6) groups, and in R.sub.4 also by halogenated groups, oxo groups and hydroxylic groups with double links. The elements represented by Z are independently from each other O, S or NH. ##STR1##

REFERENCES:
K. Yano et al., "Actinopyrones A, B and C, new physiologically active subnces. II. Physicochemical properties and chemical structures", Chemical Abstracts, vol. 105, 2261232 (1986).
Mitsui Toatsu Chemicals, "Pyrone derivatives", Chemical Abstracts, vol. 94, 15568f (1981.
Zdero et al., Phytochemistry, 26, 187-190 (1987).
Jaensch et al, ibid, 28, 3497-3501 (1989).

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