.gamma.-poly(glutamic acid) esters

Details .gamma.-poly(glutamic acid) esters .gamma.-poly(glutamic acid) esters

1992-02-07

1995-01-03

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

528328, 528330, 528331, C07K 710

Patent

active

053788079

ABSTRACT:
A method is disclosed for significantly diminishing the rate of degradation of naturally-produced .gamma.-PGA in a .gamma.-PGA-producing cell culture. Also, a method is disclosed for significantly decreasing the water solubility coefficient of naturally-produced .gamma.-PGA by forming derivatives of .gamma.-PGA. In addition, a polymer solution is disclosed which includes a polysaccharide component and a .gamma.-PGA component.

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patent: 4968742 (1990-11-01), Lewis et al.
patent: 5051185 (1991-09-01), Watanabe et al.
patent: 5057302 (1991-10-01), Johnson et al.
Chemical Abstract CA79(9):50045v (1991).
Chem. Abs. CA75(11):74844y (1991).
Roos et al., Int'l J. Pharm., 22(1): 75088 (1984).
Troy, J. Biol. Chem., 248(1): 305-315 (1973).
Troy, J. Biol. Chem., 248(1): 316-324 (1973).

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