Gamma-lactam compounds for promoting bone growth

Details Gamma-lactam compounds for promoting bone growth Gamma-lactam compounds for promoting bone growth

2009-05-26

2011-12-20

Henley, III, Raymond (Department: 1629)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C424S602000, C424S660000

Reexamination Certificate

active

08080575

ABSTRACT:
The present invention provides compounds, compositions and methods for promoting bone growth. Compounds useful in the methods of the present invention include compounds of Formula I, wherein each R1and R2is H, halogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkoxy, —OR4, —NR4R5, —SR4, —C(O)R4, —C(O)OR4, —C(O)NR4R5, —N(R4)C(O)R5, —N(R4)C(O)OR5, —N(R4)C(O)NR4R5, —OP(O)(OR4)2, —S(O)2OR4, —S(O)2NR4R5, —CN, cycloalkyl, heterocycloalkyl, aryl or heteroaryl. Each R4and R5is H or C1-6alkyl. X is O, S or NR4. Y is an aryl ring system having 6-10 ring members or a heteroaryl ring system having 5-10 ring members where 1-3 ring members are each N, O or S. Subscript n is 1 or 2. The compounds also include salts, hydrates and isomers of the compounds of the present invention.

REFERENCES:
patent: 0106988 (1987-05-01), None
patent: WO 2005/123054 (2005-09-01), None
International Search Report dated Jan. 18, 2010 issued in related International Patent Application No. PCT/US2009/045125, filed May 26, 2009.

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