Gamma-iterferon-leukotoxin gene fusions and uses thereof

Details Gamma-iterferon-leukotoxin gene fusions and uses thereof Gamma-iterferon-leukotoxin gene fusions and uses thereof

1991-10-16

1993-12-28

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 695, 435 6952, 435 697, 4351723, 435243, 4352523, 4353201, 435811, 536 231, C12N 1523, C12N 1519, C07H 1512

Patent

active

052738892

ABSTRACT:
New chimeric proteins, DNA encoding the same, and the use of these proteins in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The chimeric proteins include at least one epitope of leukotoxin fused to an active fragment of a cytokine. The chimeric proteins can be used in a vaccine composition. Also disclosed are methods of vaccination as well as methods of making the proteins employed in the vaccines.

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