Gamma-irradiated bacterial preparation having anti-tumor activit

Details Gamma-irradiated bacterial preparation having anti-tumor activit Gamma-irradiated bacterial preparation having anti-tumor activit

1997-09-15

1999-11-16

Saucier, Sandra E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Bacteria or actinomycetales

435 29, 4351738, 4352533, 435874, A01N 6300, C12Q 102, C12N 1300, C12N 120

Patent

active

059852682

ABSTRACT:
A bacterial preparation from Pseudomonas species isolated #15 ATCC 55638 that has been exposed to gamma radiation exhibits cytotoxicity that is specific for neoplastic carcinoma cells. A method for obtaining a bacterial preparation having antitumor activity consists of suspending a bacterial isolate in media and exposing the suspension to gamma radiation. A bacterial preparation of an aged culture of an amoeba-associated bacteria exhibits anti-reverse transcriptase activity. A method for obtaining a bacterial preparation having anti-reverse transcriptase activity from an amoeba-associated bacterial isolate grown to stationary phase is disclosed.

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Roberts et al. "Inhibition of mouse retroviral disease by bioactive glutaminase-asparaginase", J. Gen. Virol, 1991, 72(2), pp. 299-305.
Roberts J. "Purification and properties of a highly potent antitumor glutaminase-asparaginase from Pseudomonas 7A", The Journal of Biological Chemistry 1976, vol. 251, No. 7. pp. 2119-2123.

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