Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-05-22
2000-12-26
Kemmerer, Elizabeth
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 4, 435 697, 435325, 436501, 536 235, 530350, C12Q 100, C12N 1562, C07K 1446
Patent
active
061657336
ABSTRACT:
A mammalian protein involved in receptor-mediated endocytosis specifically binds to phosphatidylinositol 3-kinase. More specifically it binds to the Bcr homology domain of the p85 subunit of phosphatidylinositol 3-kinase. Phathoidylinositol 3-kinase also binds to platelet derived growth factor receptor. Other receptors may also bind, including those for insulin, insulin-like growth factor-1, colony stimulating factor 1, nerve growth factor, hepatocyte growth factor, stem cell growth factor, and epidermal growth factor. Mitogenesis is the consequence of the binding and internalization of these growth factors. Inhibition of the process of receptor-mediated internalization inhibits mitogenesis.
REFERENCES:
patent: 5283173 (1994-02-01), Fields et al.
Gaidarov et al. A functional phosphatidylinositol 3,4,5-trisphosphate/phosphoinositide binding domain in the clathrin adaptor AP-2 alpha subunit. Implications for the endocytic pathway. J Biol Chem, (Aug. 23, 1996) 271 (34) 20922-9.
Otsu et al. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase. Cell, (Apr. 5, 1991) 65 (1) 91-104, May 1991.
Hiles et al. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit. Cell, (Aug. 7, 1992) 70 (3) 419-29.
Pearse, "Receptors Compete for Adaptors Found in Plasma Membrane Coated Pits" EMBO Journal 7(11):3331-3336, 1988.
Pearse and Robinson, "Clathrin, Adaptors, and Sorting" Annu. Rev. Cell Biol. 6:151-171, 1990.
Robinson, "Cloning and Expression of .gamma.-Adaptin, a Component of Clathrin-Coated Vesicles Associated with the Golgi Apparatus" J. Cell Biology 111(No. 6, pt. 1):2319-2326, Dec., 1990.
Trowbridge, "Endocytosis and Signals for Internalization" Current Opinion Cell Biology 3:634-641, 1991.
Sorkin and Carpenter, "Interaction of Activated EGF Receptors with Coated Pit Adaptins" Science 261:612-615, Jul., 1993.
Cohen et al., "The Conserved C-Terminal Domain of the Bovine Papillomavirus E5 Oncoprotein can Associate with an .alpha.-Adaptin-Like Molecular: a Possible Link Between Growth Factor Receptors and Viral Transformation" Molecular and Cellular Biology 13(10):6462-6468, Oct., 1993.
Zhang et al., "Synaptotagmin I is a High Affinity Receptor for Clathrin AP-2: Implications for Membrane Recycling" Cell 78:751-760, Sep., 1994.
Ohno et al., "Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins" 269:1872-1875, Sep., 1995.
Okabayashi et al., "Interaction of Shc with Adaptor Protein Adaptins" J. Biological Chemistry 271(9):5265-5269, 1996.
Lewin et al., Molecular Biology of the Cell (Supplement) (1996) 7:279a.
Cen Hui
Williams Lewis T.
Blackburn Robert P.
Chiron Corporation
Kemmerer Elizabeth
Potter Jane E. R.
Romeo David S.
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