.gamma.-glutamyl-p-aminoanilide derivatives for measuring activi

Details .gamma.-glutamyl-p-aminoanilide derivatives for measuring activi .gamma.-glutamyl-p-aminoanilide derivatives for measuring activi

1978-05-30

1979-12-04

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving hydrolase

260507R, 562450, G01N 3314

Patent

active

041771095

ABSTRACT:
A .gamma.-glutamyl-p-aminoanilide derivative of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently lower alkyl; and R.sup.3 is hydrogen, lower alkyl, carboxyl or sulfo, can be produced by reacting a N-phthalyl-.gamma.-glutamyl-p-aminoanilide derivative with hydrazine. The .gamma.-glutamyl-p-aminoanilide derivative can be used as a substrate for measuring .gamma.-glutamyl transpeptidase activity in a living sample.

REFERENCES:
patent: 3892631 (1975-07-01), Carroll
patent: 3986931 (1976-10-01), Bernt et al.
patent: 4087331 (1978-05-01), Bucolo et al.
Rosalki et al, Clinical Chemistry, vol. 20, No. 9, pp. 1121-1124, (1974).

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