Gamma-glutamyl-4-azoanilides, process for the preparation thereo

Details Gamma-glutamyl-4-azoanilides, process for the preparation thereo Gamma-glutamyl-4-azoanilides, process for the preparation thereo

1988-08-11

1990-07-24

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving transferase

435 24, 435810, C12Q 148, C12Q 136

Patent

active

049435264

ABSTRACT:
The present invention provides gamma-glutamyl-4-azoanilides, processes for their preparation and their use as substrates for gamma-glutamyl transferase determination, of the formula ##STR1## wherein X is alkyl, --(CH.sub.2).sub.m --COOH or --O--(CH.sub.2).sub.n --COOH wherein m is 0-4 and n is 1-4; R is optionally substituted p-nitrophenyl; an optionally substituted thiophene residue; an optionally substituted thiazole residue; an optionally substituted benzothiazole residue; an optionally substituted benzoisothiazole residue; an N-alkylthiazole residue; or an optionally substituted 1,3,5-thiodiazole residue; as well as the alkali metal, alkaline earth metal and ammonium salts thereof.

REFERENCES:
patent: 4560650 (1985-12-01), Bauer et al.
Walter, Methods of Enzymatic Analysis, vol. V, Bergmeyer (Ed.), Verlay Chemie, Weinheim, 270-277 (1984), 3rd Edition.

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