Gamma-Glutamyl-4-azoanilides

Details Gamma-Glutamyl-4-azoanilides Gamma-Glutamyl-4-azoanilides

1987-01-27

1988-09-06

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Azo

424 2, 424 71, 436 43, 514155, 514156, 534566, 534582, 534581, 534591, 534728, 534753, 534777, 534795, 534804, 534853, 534854, 534887, C07C10706, C09B 4312, C09B 43136, G01N 3100

Patent

active

047694475

ABSTRACT:
The present invention provides gamma-glutamyl-4-azoanilides, processes for their preparation and their use as substrates for gamma-glutamyl transferase determination, of the formula ##STR1## wherein X is alkyl, --(CH.sub.2).sub.m --COOH or --O--(CH.sub.2).sub.n --COOH wherein m is 0-4 and n is 1-4; R is optionally substituted p-nitrophenyl; an optionally substituted thiophene residue; an optionally substituted thiazole residue; an optionally substituted benzothiazole residue; an optionally substituted benzoisothiazole residue; an N-alkylthiazole residue; or an optionally substituted 1,3,5-thiodiazole residue; as well as the alkali metal, alkaline earth metal and ammonium salts thereof.

REFERENCES:
patent: 2304820 (1942-12-01), Hanford et al.
patent: 2398367 (1946-04-01), Felix et al.
patent: 3528961 (1970-09-01), Miles et al.
patent: 4087420 (1978-05-01), Heinrich et al.
Goodman et al., J. Amer. Chem. Soc., vol. 88, pp. 5010 to 5015 (1966).

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