Gamma-globulin preparation for intravenous administration

Details Gamma-globulin preparation for intravenous administration Gamma-globulin preparation for intravenous administration

1984-02-24

1987-09-08

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

530387, A61K 39395

Patent

active

046923314

ABSTRACT:
A dry .gamma.-globulin preparation capable of intravenous injection which is obtainable by polyethylene glycol fractionation of plasma is improved in its water-solubility and stability against increase of anticomplement activity and decrease of antibody titer by purifying the .gamma.-globulin fraction with respect to protein to render the residual polyethylene glycol substantially not detectable in its 5% W/V solution, adding 0.2 to 2 parts by weight of glucose based on 1 part of .gamma.-globulin, and lyophilizing its solution.

REFERENCES:
patent: 4124576 (1978-07-01), Coval
patent: 4165370 (1979-08-01), Coval
patent: 4362661 (1982-12-01), Ono et al.
patent: 4374763 (1983-02-01), Takage
patent: 4482483 (1984-11-01), Curry et al.
Rahn, Physical Method of Sterilization of Microorganisms, Bact. Rev., 9, pp. 1 and 24, 1945.
Deiwest Abstract of Japanese Laid Open Patent Application No. 3047-515, 1978.

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