Gamma-globulin injectable solutions containing sorbitol

Details Gamma-globulin injectable solutions containing sorbitol Gamma-globulin injectable solutions containing sorbitol

1988-02-05

1989-10-24

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Lymphokine

424101, 514 8, 514 21, 514777, 530387, A61K 39395, C08L 8900

Patent

active

048760889

ABSTRACT:
An intravenously injectable solution of chemically unmodified .gamma.-globulin having a complete molecular structure is disclosed, said solution containing sorbitol as a stabilizer and having a low electrical conductivity and a pH of about 5.5.+-.0.2. The injectable solution does not cause an increase of .gamma.-globulin polymer, a rise of anticomplement titer, or impairment of the activities of the .gamma.-globulin, either during preservation or upon administration to a living body.

REFERENCES:
patent: 4396608 (1983-08-01), Tenold
patent: 4412990 (1983-11-01), Lundblad et al.
patent: 4439421 (1984-03-01), Hooper et al.
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4477432 (1984-10-01), Hardie
The Lancet, Nov. 19, 1983, Welch et al., pp. 1198-1199.

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