Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Patent
1993-11-19
1997-02-11
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
4241341, 4241431, 4241781, 530300, 5303871, 53038825, 5303891, 436500, 436548, C07K 14725
Patent
active
056018223
ABSTRACT:
The present invention provides purified polypeptides which comprise at least a portion of a .delta. T cell receptor polypeptide, a .gamma. T cell receptor polypeptide, a .gamma., .delta. T cell receptor complex or a .gamma., .gamma. T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided.
Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.
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Brenner Michael B.
Ip Stephen H.
Krangel Michael S.
Seidman Johnathan
Strominger Jack L.
Dana Farber Cancer Institute
Nucker Christine M.
President and Fellows of Harvard College
Scheiner Lautlie
T Cell Sciences, Inc.
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