.GAMMA., .delta.T cell receptor and methods and detection

Details .GAMMA., .delta.T cell receptor and methods and detection .GAMMA., .delta.T cell receptor and methods and detection

1987-02-19

1994-08-23

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

435 71, 435 724, 5303871, 5303881, 53038875, 530868, 436506, A61K 3514, C07K 300

Patent

active

053409213

ABSTRACT:
The present invention provides purified polypeptides which comprise at least a portion of a .delta.T cell receptor polypeptide, a .gamma.T cell receptor polypeptide, a .gamma., .delta.T cell receptor complex or a .gamma., .gamma.T cell receptor complex. Substances capable of forming complexes with these polypeptides are also provided.
Additionally, methods for detecting T cells which have within them or on their surfaces a polypeptide of the present invention are provided. Moreover, methods for diagnosing immune system abnormalities are provided which comprise measuring in a sample from a subject the number of T cells which have within them or on their surfaces a polypeptide of the present invention.

REFERENCES:
patent: 4713332 (1987-12-01), Mak
Nowill et al., 1986, J. Exp. Med. 163: 1601-1606 [DA].
Lomant and Fairbanks, J. Mol. Biol. 104: 243-261 (1976).
Fabbi et al., Eur. J. Immunol. 15: 821-827 (1985).
Maxam and Gilbert, Meth. Enzymol., 65: 499-560 (1980).
Sanger et al., Proc. Natl. Acad. Sci. U.S.A. 74(12): 5463-5467 (1977).
Maniatis et al., Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y. (1982).
DeRobertis and DeRobertis, Cell and Mol. Biology, 7th Ed., Saunders College, Pa. (1980).
Quertermous et al., Science, vol. 231, Jan. 1986, pp. 231-255.
Dialynas et al., PNAS USA, vol. 83, Apr. 1986, pp. 2619-2623.
Sevier et al., Clin. Chem.; vol. 27(11), 1981, pp. 1797-1806.
Kyte, J. Mol. Biol., vol. 157, 1982, pp. 105-132.
Hopp, PNAS USA, vol. 78, Jun. 1981, pp. 3824-3828.
Krissansen et al., EMBO J., vol. 5(8), 1986, pp. 1799-1808.
Elsen et al., Proc. Natl. Acad. Sci. USA, vol. 83, May 1986, pp. 2944-2948.
Pardoll et al., Faseb J. 1: 103-109 (1987).
Reilly et al., Nature 321: 878-880 (Jun. 1986).
Rupp et al., Nature 321: 876-878 (Jun. 1986).
Haars et al., J. Exp. Med. 164: 1-24 (Jul. 1986).
Moingeon et al., Nature 323: 638-640 (Oct. 1986).
Jones et al., Nature 323: 635-638 (Oct. 1986).
Lanier and Weiss, Nature 324: 268 (1986).
LeFranc et al., Proc. Natl. Acad. Sci. U.S.A. 83: 9596-9600 (1986).
European Patent Application Pub. No. 200, 350, published Nov. 5, 1986.
MacLeod et al., Proc. Natl. Acad. Sci. U.S.A. 83: 6989-6993 (1986).
Brenner et al., Nature (London) 322: 145-149 (1986).
Tunnacliffe et al., EMBO J. 5: 1245-1252 (1986).
LeFranc et al., Cell 45: 237-246 (1986).
Mak, U.S. Patent No. 4,713,332, filed Feb. 6, 1984, issued Dec. 15, 1987.
Royer et al., J. Exp. Med. 160: 947-952 (1984).
Reinherz et al., U.S. Patent No. 4,550,086, filed Feb. 16, 1983, issued Oct. 29, 1985.
Goldenberg, U.S. Patent No. 4,444,744, filed Sep. 3, 1982, issued Apr. 24, 1984.
Allison et al., J. Immunol. 129, 2293-2300 (1982).
Kappler et al., Cell 35, 295-302 (1983).
Acuto et al., J. Exp. Med. 158, 1368-1373 (1983).
Haskins et al., J. Exp. Med. 157, 1149-1169 (1983).
Acuto et al., Cell 34, 717-726 (1983).
Samelson and Schwartz, Immunological Reviews 81, 131-144 (1984).
Hedrick et al., Nature 308, 153-158 (1984).
Yanagi et al., Nature 308, 145-149 (1984).
Saito et al., Nature 312, 36-40 (1984).
Sim et al., Nature 312, 771-775 (1984).
Chien et al., Nature 312, 31-35 (1984).
Siu et al., Cell 37, 393-401 (1984).
Patten et al., Nature 312, 40-46 (1984).
Yoshikai et al. Nature 312, 521-524 (1984).
Yanagi et al., Proc. Natl. Acad. Sci. U.S.A. 82, 3430-3434 (1985).
Hedrick et al., Proc. Natl. Acad. Sci. U.S.A. 82, 531-535 (1985).
Becker et al., Nature 317, 430-434 (1985).
Tonegaw, Scientific American, pp. 122-131 Oct. 1985.
Yague et al., Cell 42, 82-87 (1985).
Blanckmeister et al., J. Exp. Med. 162: 851-863 (1985).
Dembic et al., Nature 320, 232-238 (1986).
Saito et al., Nature 309, 757-762 (1984).
Kranz et al., Nature 313, 752-755 (1985).
Snodgrass et al., Nature 315, 232-233 (1985).
Lefranc and Rabbitts, Nature 316, 464-466 (1985).
Murre et al., Nature 316, 549-552 (1985).
Heilig et al., Nature 317, 68-70 (1985).
Hayday et al., Cell 40, 259-269 (1985).
Dialynas et al., Proc. Natl. Acad. Sci. U.S.A. 83, 2619 (1986).
Iwamoto et al., J. Exp. Med. 163, 1203-1212 (1986).
Zauderer et al., J. Exp. Med. 163, 1314-1318 (1986).
Caccia et al., Cell 37, 1091-1099 (1984).
Kranz et al., Science 227, 941-944 (1985).
Brenner et al., J. Exp. Med. 160, 541-551 (1984).
Spits et al., J. Immunol. 135, 1922-1928 (1985).
Reinherz et al., Cell 30, 735-743 (1982).
Borst et al., J. Biol. Chem. 258, 5135-5141 (1983).
Reinherz et al., Proc. Natl. Acad. Sci. U.S.A. 80, 4104-4108 (1983).
Meuer et al., J. Exp. Med. 157, 705-719 (1983).
Oettgen et al., J. Biol. Chem. 259, 12039-12048 (1984).
Weiss and Stobo, J. Exp. Med. 160, 1284-1299 (1984).
Allison and Lanier, Nature 314, 107-109 (1985).
Brenner et al., Cell 40, 183-190 (1985).
Van den Elsen et al., Proc. Natl. Acad. Sci. U.S.A. 82, 2920-2924 (1985).
Ohashi et al., Nature 316, 606-609 (1985).
Krawinkel et al., Cold Spring Harb. Symp. Quanti. Biol. 4, 285-294 (1976).
Binz and Wigzell, Cold Spring Harb. Symp. Quant. Biol. 4, 275-284 (1976).
Binz and Wigzell, J. Exp. Med. 154, 1261-1278 (1981).
Kung et al., Int. J. Dermat. 22, 67-73 (1983).
Krensky and Clayberger, Transplantation 39(4): 339-348 (1985).
de la Hera et al., Proc. Natl. Acad. Sci. U.S.A. 82, 6268-6271 (1985).
Levin, L. S., et al., J. Pediatrics 90(1), 55-61 (1977).
Griscelli et al., (1980), in Primary Immunodeficiencies, Seligmann, M. and Hitzig, W. H., eds., Elsevier/North-Holland, pp. 499-503.
Hadam, et al., (1984), in Progress in Immunodeficiency Research and Therapy I, Griscelli, C. and Vossen, J., eds., Elsevier Science Publishers B.V., pp. 43-50.
Chan and Takei, J. Immunol. 136(4), 1346-1353 (1986).
Kung et al., U.S. Patent No. 4,614,720, filed Oct. 4, 1982.

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