Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1996-04-24
1999-01-05
Loring, Susan A.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4352523, 4353201, 435239, 536 2353, 536 235, 53038822, C12P 2104, C12P 2106, C12N 120, C12N 1500
Patent
active
058561404
ABSTRACT:
A polypeptide which specifically binds to the .gamma.-chain of the human interleukin-2 receptor and selectively inhibits the binding of the .gamma.-chain of human interleukin-2 receptor to the .beta.-chain of the same is provided. The polypeptide has an activity of blocking the human interleukin-2 response. Also provided are an immunosuppressant containing the polypeptide, a DNA gene coding for the polypeptide, a recombinant DNA having the gene, a transformant having the recombinant DNA, and a method for producing the intended polypeptide by incubating the transformant. The novel polypeptide can be used independently, or with substances capable of inhibiting the binding of interleukin-2 to the interleukin-2 receptor, as a medicine for preventing the rejection of grafts after transplantation and also for curing inflammatory diseases such as allergic diseases and autoimmune diseases.
REFERENCES:
Bird, R.E. et al, Science, 242:423-426, Oct. 21, 1988.
Tanalsa, Y. et al, Microbiol Immun, 29(10):959-972, 1985.
Talseshita, T. et al, Science, 257:379-382, Jul. 17, 1992.
S.D. Voss et al, "Identification of a direct interaction between interleukin 2 and th p. 64 interleukin 2 receptor .gamma. chain", March 1993, Proc. Natl. Acad. Sci. USA, vol. 90., pp. 2428-2432.
M. Kondo et al, "Sharing of the interleukin-2 (IL-2) receptor .gamma. chain between receptors for IL-2 and IL-4", Dec. 17, 1973, Science, vol. 262., pp. 1874-1877.
M. Fujii et al, "High-and low-affinity interleukin 2 receptors: Distinctive effects of monoclonal antibodies", Sep. , 1986, The Journal of Immunology, vol. 137., No. 5., pp. 1552-1556.
Hamuro Junji
Kanayama Yuka
Nakazawa Harumi
Shimamura Toshiro
Sugamura Kazuo
Ajinomoto Co. Inc.
Kazuo Sugamura
Loring Susan A.
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