Gamma-aminobutyric acid derivatives, process for production ther

Details Gamma-aminobutyric acid derivatives, process for production ther Gamma-aminobutyric acid derivatives, process for production ther

1985-07-09

1987-10-27

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514554, 514563, 560170, 562567, 26050111, C07C10348, A61K 3122

Patent

active

047030615

ABSTRACT:
A compound which is 4-(3,5-dihydroxy-3-methylpentylamide)butyric acid or its pharmaceutically acceptable salt or ester; this compound being produced by reacting a salt or an ester of gamma-aminobutyric acid with beta-hydroxy-beta-methyl-delta-valerolactone, and as required, converting the resulting compound in the form of a salt or ester to a free acid, or as required, converting the resulting compound in the form of a free acid to its pharmaceutically acceptable salt or ester; and useful as a medicament for preventing or treating an impediment in cerebral function.

REFERENCES:
patent: 2234680 (1941-03-01), Moore
patent: 2271872 (1942-02-01), Mitchell
patent: 2414682 (1947-01-01), Williams
patent: 2442143 (1948-05-01), Pickel
patent: 2848489 (1958-08-01), Kagan
patent: 2856421 (1958-10-01), Hasbrouck
Burger, "Medical Chemistry," Part II, 3rd Ed., pp. 1196-1197 & 1222-1227 (1970).

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