Gallium dimercaptosuccinate as a novel tumor imaging agent

Details Gallium dimercaptosuccinate as a novel tumor imaging agent Gallium dimercaptosuccinate as a novel tumor imaging agent

1994-12-15

1997-06-17

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 137, 424 165, 424 96, 534 10, A61K 5100, A61M 3614

Patent

active

056394390

ABSTRACT:
Novel tumor imaging agents in which the dimercaptosuccinic acid was dissolved in phosphate buffer and labelled with radioisotope gallium. The product of gallium dimercaptosuccinate has been characterized by a variety of experiments including serum stability, biodistribution and imaging experiment. As the results, the compound of gallium dimercaptosuccinate has been confirmed as a novel radiopharmaceutical for tumor imaging agent.

REFERENCES:
patent: Re31463 (1983-12-01), Loberg et al.
patent: 4017596 (1977-04-01), Loberg et al.
patent: 4233285 (1980-11-01), Winchell et al.
patent: 4264468 (1981-04-01), Neirinckx et al.
patent: 4361544 (1982-11-01), Goldenberg
patent: 4448763 (1984-05-01), Triplett
patent: 4720379 (1988-01-01), Heyl et al.
patent: 5019369 (1991-05-01), Presant et al.
patent: 5079346 (1992-01-01), Kung
patent: 5399338 (1995-03-01), Born et al.
patent: 5428139 (1995-06-01), Kiefer et al.
Saji et al (1980). Radioisotopes, vol. 29, No. 1, pp. 7-12 "Enhancement of .sup.67 Ga-Citrate Tumor-to-Blood Ratios by Chelating Agent".
Green et al. "Gallium-68 1,1,1-tris (5-methoxysalicylaldiminomethyl) Ethane: A Potential Tracer for Evaluation of Regional Myocardial Blood Flow", The Journal of Nuclear Medicine, 26, pp. 170-180 (1995).
Burns et al. "Reversal of Gallium Arsenide-Induced Suppression of the Antibody Response by a Mixed Disulfide Metabolite of Meso -2,3-dimelcaptosuccinic acid." The Journal of Pharmacology and Experimental Therapeutics, vol. 264, No. 2, pp. 695-700.
Green et al, "Gallium Radiopharmaceutical Chemistry," Nucl. Med. Bio. vol. 6, No. 5, pp. 435-448 (1989).
Chemical Principles, .COPYRGT.1985, p. 237. "The Periodic Table and the Properties of Metals" by Masterton et al. The Merck Index, 9th edition, p. 560, compound 4191.

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