Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-03-06
1993-03-23
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514188, 546 6, 556 1, 540486, A61K 31555, C07D22310, C07D71194
Patent
active
051964120
ABSTRACT:
The present invention relates to compounds of gallium (III) which can be given orally to achieve high serum levels of gallium (III) for the treatment of hypercalcemia of malignancy and related disorders of bone metabolism. Complexes of gallium (III) of the formula (I) ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 n-alkyl and R.sub.2 is H or C.sub.1 -C.sub.2 alkyl, or R.sub.1 and R.sub.2 together form tetra- or penta-methylene and wherein said complex is useful in increasing calcium content of bone tissue and decreasing bone resorption, are used in an amount sufficient to cause an increase in calcium content of said bone and to cause decreased bone resorption.
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patent: 4529593 (1985-07-01), Warrell et al.
patent: 4704277 (1987-11-01), Bockman
Ivanov, Chem. Abs. 115, 84071 (1991).
Journal of Organometallic Chemistry, vol. 99, No. 2, (1975) pp. 223-230, Schewering et al., "Dialkylmetallhydroxamate . . . ".
Abrams Michael J.
Bradley Fontaine C.
Frost Danielle T.
Giandomenico Chris M.
Vollano Jean F.
Berch Mark L.
Johnson Matthey Inc.
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