Gallium compounds

Details Gallium compounds Gallium compounds

1992-05-19

1994-01-25

Dees, Jose

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514492, 556 1, 556 32, A61K 3714, A61K 3128, C07F 500

Patent

active

052815781

ABSTRACT:
Gallium(III) complexes of general formula I, ##STR1## in which X=O.sub.2 CR.sup.2, halogen, NO.sub.3 or -OA, R.sup.1 =H, alkyl, alkoxy, halogen, NO.sub.2 or amino, R.sup.2 =alkyl, alkoxy or aryl, each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 =H or alkyl and n=0, 1 or 2, or when n=0 and R.sup.3 and R.sup.6 both=H, then R.sup.4 and R.sup.5 together may form tetramethylene, and A=an identical gallium complex moiety to that to which the oxygen atom is linked, are well absorbed orally, and are indicated as medicaments for hypercalcemia and for cancer chemotherapy.

REFERENCES:
patent: 2778843 (1957-01-01), Brown et al.
Canadian Journal of Chemistry, vol. 59, pp. 94-99 (1981).
Chong et al., Canadian Journal of Chemistry, vol. 59, No. 1, 94-99 (Jan. 1981).

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