Gallium compositions for the treatment of liver cancer and...

Details Gallium compositions for the treatment of liver cancer and... Gallium compositions for the treatment of liver cancer and...

2007-03-08

2011-12-13

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

C556S001000

Reexamination Certificate

active

08076371

ABSTRACT:
Provided are compositions and methods to treat liver cancer and related disorders in human or veterinary individuals. Primary liver cancers, including those metastatic to other parts of the body, as well as cancers metastatic to the liver cancer, can be treated and/or prevented with the compositions and methods of the present invention. The methods comprise the administration of pharmaceutically acceptable gallium compositions, including gallium maltolate. Routes of administration include, without limitation, oral, intravenous, intratumoral, and into blood vessels as part of chemoembolization therapy. Some of the compositions and methods disclosed herein are applicable to cancers other than liver cancer.

REFERENCES:
patent: 6087354 (2000-07-01), Bernstein
patent: 2005/0054708 (2005-03-01), Nichols et al.
patent: 2005/0137185 (2005-06-01), Lee et al.
patent: 1235017 (1987-04-01), None
Krecic-Shepard ME, Shepard DR, Mullet D, Apseloff G, Weissbrode SE, Gerber N (1999) Gallium nitrate suppresses the production of nitric oxide and liver damage in a murine model of LPS-induced septic shock. Life Sciences 65(13):1359-1371.

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