Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1998-01-29
1999-12-07
MacMillan, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
549210, A61K 31555
Patent
active
059983973
ABSTRACT:
Disclosed are pharmaceutical compositions that comprise gallium complexes of 3-hydroxy-4-pyrones. These compositions provide enhanced gallium bioavailability particularly when orally administered as compared to the gallium bioavailability achieved by use of pharmaceutical compositions containing gallium salts. Compositions included in this invention are useful in providing gallium to humans and other mammals for a wide variety of medical and veterinary applications, including the treatment, prevention, or diagnosis of hypercalcemia, certain cancers, certain disorders of calcium homeostasis, and certain bone diseases including osteoporosis, osteopenia, and Paget's disease.
REFERENCES:
patent: 2460188 (1949-01-01), O'Kane
patent: 3799945 (1974-03-01), D'Amico
patent: 3927195 (1975-12-01), Messora
patent: 4529593 (1985-07-01), Warrell et al.
patent: 4575502 (1986-03-01), Hider et al.
patent: 4596710 (1986-06-01), Collery
patent: 4665064 (1987-05-01), Hider et al.
patent: 4686104 (1987-08-01), Bockman et al.
patent: 4704277 (1987-11-01), Bockman et al.
patent: 5175006 (1992-12-01), Matkovic et al.
patent: 5177068 (1993-01-01), Callingham et al.
Adamson et al. (1975), "Studies on the Antitumor Activity of Gallium Nitrate (NSC-15200) and Other Group IIIa Metal Salts, " Cancer Chemotherapy Reports, Part 1, 59(3):599-610.
Barr et al. (1986), Effects of the Pyrones, Maltol and Ethyl Maltol, on Iron Absorption from the Rat Small Intestine, J. Pharm. Pharmacol. 39:203-211.
Bockman et al. (1983), "Abstracts: Bone Metabolism and Cell Biology, " Calcified Tissue International35(4-5):637.
Farrar et al. (1988), "Tissue Distribution of Gallium Following Administration of the Gallium-Maltol Complex in the Rat, " Food Chem. Toxic. 26:523-525.
Finnegan et al. (1987), "Neutral Water-Soluble Post-Transition Metal..., " Inorganic Chemistry26:2171-2176.
Foster et al. (1987), "Galliuim Nitrate: The Second Metal with Clinical Activity, " Cancer Treatment Reports70(11):1311-1318.
Hart et al. (1971), "Antitumor Activity and Toxicity of Salts of Inorganic Group IIIa Metals: Aluminum, Gallium, Indium, and Thallium, " Proc. Natl. Acad. Sci. USA 68(7):1623-1626.
Warrell et al., (1989) "Gallium in the Treatment of Hypercalcemia and Bone Metastasis, " Important Advances in Oncology, chapter 12 (Philadelphia: J.B. Lippincott Company).
MacMillan Keith D.
Maher David W.
Reed Dianne E.
LandOfFree
Gallium complexes of 3-Hydroxy-4-pyrones to treat or prevent bon does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Gallium complexes of 3-Hydroxy-4-pyrones to treat or prevent bon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gallium complexes of 3-Hydroxy-4-pyrones to treat or prevent bon will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-823932