Galenical forms of corticoids for administration perlingually an

Details Galenical forms of corticoids for administration perlingually an Galenical forms of corticoids for administration perlingually an

1988-10-07

1991-10-29

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424435, 424490, A61K 928

Patent

active

050614932

ABSTRACT:
In these new galenical forms the corticoid is contained, in strictly controlled and reproducible amounts, in solid supports provided for an extended release of the active ingredient perlingually and sublingually.
The corticoid is preferably methylprednisolone.
The galenical forms can be prepared as follows:
dissolving the corticoid in a solvent,
preparing dilutions with different concentrations,
fractionating each of these dilutions into subdilutions,
impregnating by multi-impregnation or fractionated impregnation a pharmaceutically acceptable solid support with each of the subdilutions, each of said impregnation stages being followed by a drying in forced air dried at a temperature not more than 35.degree. C.

REFERENCES:
patent: 4259314 (1981-03-01), Lowey
patent: 4279900 (1981-07-01), Bodor et al.
patent: 4292299 (1981-09-01), Suzuki et al.
patent: 4432966 (1984-02-01), Zeitoun et al.

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