Galenical form of administration of betahistine and its derivati

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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424 21, 424 32, 424 33, 424 35, 424 81, A61K 922, A61K 932

Patent

active

042294282

ABSTRACT:
There is provided a medicament in a form having surprising effectiveness against vertigo in Meniere's syndrome. This medicament comprises, as active ingredient, betahistinemethanesulfonate. The medicament further comprises a core of pharmaceutially acceptable thereapeutically inert carrier material having the active ingredient absorbed thereon, said active ingredient being covered with a dialysis membrane said membrane further carrying a second layer of active ingredient which, if desired, is itself absorbed upon a layer of therapeutically inert carrier material and is covered with a further dialysis membrane. There may be utilized a plurality of substantially concentric layers of active material suitably absorbed on the carrier, and covered with a dialysis membrane to provide a long-acting medicament form.

REFERENCES:
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patent: 3538214 (1970-11-01), Polli et al.
patent: 3775537 (1973-11-01), Lehmann et al.
patent: 3835221 (1974-09-01), Fulberth et al.
patent: 3954959 (1976-05-01), Pedersen
patent: 4083949 (1978-04-01), Benedikt
Merck Index 9th Ed (1976), Merck & Co., Rahway, N.J., p. 1208, #1206, "Betahistine" (HCL Vasodilator).
Fossel Chem. Abstr. 75, #25394t (1971) of Ger. Off. 2,035,301, Feb. 18, 1971.
Konzett et al., Chem. Abstr. 75 #62007q (1971) of J. Pharmacol. Exp. Thor. 1971 178(1).
Palazzoadriano et al., Chem. Abstr. 79 #28512n (1973) of Boll. Soc. Ital. Cardiol (1970) 15(s): 388-401.

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