Galenical form of administration of betahistine and its derivati

Details Galenical form of administration of betahistine and its derivati Galenical form of administration of betahistine and its derivati

1979-04-05

1980-10-21

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 21, 424 32, 424 33, 424 35, 424 81, A61K 922, A61K 932

Patent

active

042294282

ABSTRACT:
There is provided a medicament in a form having surprising effectiveness against vertigo in Meniere's syndrome. This medicament comprises, as active ingredient, betahistinemethanesulfonate. The medicament further comprises a core of pharmaceutially acceptable thereapeutically inert carrier material having the active ingredient absorbed thereon, said active ingredient being covered with a dialysis membrane said membrane further carrying a second layer of active ingredient which, if desired, is itself absorbed upon a layer of therapeutically inert carrier material and is covered with a further dialysis membrane. There may be utilized a plurality of substantially concentric layers of active material suitably absorbed on the carrier, and covered with a dialysis membrane to provide a long-acting medicament form.

REFERENCES:
patent: 3247066 (1966-04-01), Milosovich
patent: 3538214 (1970-11-01), Polli et al.
patent: 3775537 (1973-11-01), Lehmann et al.
patent: 3835221 (1974-09-01), Fulberth et al.
patent: 3954959 (1976-05-01), Pedersen
patent: 4083949 (1978-04-01), Benedikt
Merck Index 9th Ed (1976), Merck & Co., Rahway, N.J., p. 1208, #1206, "Betahistine" (HCL Vasodilator).
Fossel Chem. Abstr. 75, #25394t (1971) of Ger. Off. 2,035,301, Feb. 18, 1971.
Konzett et al., Chem. Abstr. 75 #62007q (1971) of J. Pharmacol. Exp. Thor. 1971 178(1).
Palazzoadriano et al., Chem. Abstr. 79 #28512n (1973) of Boll. Soc. Ital. Cardiol (1970) 15(s): 388-401.

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