Galenic form of 5-nitromidazole derivatives which is effective f

Details Galenic form of 5-nitromidazole derivatives which is effective f Galenic form of 5-nitromidazole derivatives which is effective f

1995-01-11

1996-08-27

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424468, 424469, 424470, 424489, 424490, A61K 922, A61K 926, A61K 952, A61K 954

Patent

active

055499112

ABSTRACT:
The present invention relates to a galenic form of 5-nitroimidazole derivatives which is characterized in that it comprises a combination of microgranules of 5-nitroimidazole derivatives consisting, on the one hand, of gastroresistant microgranules and, on the other hand, of prolonged-release microgranules, the pharmaceutical compositions comprising them and the microgranules as intermediates in the preparation of the form according to the invention.

REFERENCES:
Lambov et al Pharmazie 49(6): 438-440 (1994) (pp. 26-27).
Shell WO/PCT93/18755111 (Sep. 30, 1993).
Tsankov et al Pharm, Ind. 53(7): 695-698 (1991) (p. 31).
Chemtob et al I Drug Dev. Ind. Pharm. 15(8): 1161-1174 (1989).
Leucata et al I Clujul Med. 59(4): 348-352 (1986).
Leucata et al II Clujul Med. 59(1): 74-79 (1986).
Mandal et al. Indian Drugs 23(7): 400-403 (1986).
Chemtob et al (II) Int. J. Pharm. 29(1): 1-7 (1986).
Chemtob et al (III) Int. J. Pharm. 29(1): 83-92 (1986).
WO91/17744-PCT International Application Publication-Gary R. Jernberg, 1981.
Chemical Abstracts, vol. 94, No. 12, abstract No. 90226w; "icroencapsulation of metronidazol" (1981).
Indian J. Pharm Sci., vol. 42, No. 2, M. R. Baichwal Et Al.; "Microencapsulation Of Metronidazole" (1980).

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