Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1995-06-06
1996-11-19
Scheiner, Toni R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530326, 530325, C07K 500, C07K 700, C07K 1700, A61K 3800
Patent
active
055762964
ABSTRACT:
A galanin antagonist which is a galanin receptor ligand is described. New peptides, Galanin (1-12)-Pro-Substance P(5-11), Galanin (1-12)-Pro-Bradykinin(2-9), Galanin (1-12)-Pro-Pro-Pro- (Leu.sup.5 -Enkephalin (5-1), Galanin (1-12)-Pro-Lys(.epsilon.-NH-)Pro-(Leu5-Enkephalin (5-1) and functional analogues and functional derivatives thereof are disclosed. The peptides are used in pharmaceutical preparations to treat a disorder in a mammal which depends on the physiological function of galanin at the galanin receptor.
REFERENCES:
Fisone, et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 9588-9591 (1989).
Lagny-Pourmir, et al., Peptides, vol. 10, pp. 757-761 (1989).
Hermansen, et al, Acta Endocr. (Copenh) 121:545-550 (1989).
Dunning, et al., Diabetes, vol. 37, pp. 1157-1162 (1988).
Lindskog, et al., European Journal of Pharmacology, 210, pp. 183-188 (1992).
Wiesenfeld-Hallin, et al., Proc. Natl. Acad. Sci. USA, vol. 89, pp. 3334-3337 (1992).
Bartfai, et al., Proc. Natl. Acad. Sci. USA, vol. 88, pp. 10961-10965 (1991).
Cecil Textbok of Medicine, 1992 pp. 2076-2077.
Ahr en Bo
Bartfai Tamas
Consolo Silvana
H okfelt Tomas
Land Tiit
Aktiebolaget Astra
Huff Sheela J.
Scheiner Toni R.
LandOfFree
Galanin antagonist does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Galanin antagonist, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Galanin antagonist will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-541056