Galactosylceramide analogs, and β-glucocerebrosidase...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C514S024000, C514S025000, C536S004100, C536S017200, C536S017600, C536S018700, C536S053000, C536S054000

Reexamination Certificate

active

10482110

ABSTRACT:
Galactosylceramide analogues represented by the following formula (1) or (2).(wherein X and Y each represent S or O, R1and R2each represent an alkyl group or an alkenyl group each having 9 to 35 carbon atoms. R3represents an alkyl group or an alkenyl group each having 2 to 30 carbon atoms.)It is provided a β-glucocerebrosidase activator which is easily available, and external skin preparations and a method of activating β-glucocerebrosidase, in which improvement in formation of horny layer transmission barrier is expected by activating β-glucocerebrosidase so that an improved effect in rough skin is also expected.

REFERENCES:
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patent: 8-116971 (1996-05-01), None
patent: WO 95/25736 (1995-09-01), None
patent: WO 95/25736 (1995-09-01), None
Faroux-Corlay et al., Synthesis of Single- and Double-Chain Fluorocarbon and Hydrocarbon Galactosyl Amphiphiles and their anti-HIV-1 Activity, Carbohydrate Research, vol. 327, issue 3, pp. 223-260, Jul. 2000.
Sasaki et al., “Synthesis of Novel Galactosyl Ligands for Liposomes and the Influence of the Spacer on Accumulation in the Rat Liver”, Biological and Pharmeucitical Bulletin, vol. 18, No. 5, pp. 740-746, May 1995.
P.D. Mier et al., “Lysosomal Hydrolases of the Epidermis”, British Journal of Dermatology, vol. 95, 1976, pp. 271-274.
B. Faroux-Corlay et al., “Synthesis of Single- and Double-Chain Fluorocarbon and Hydrocarbon Galactosyl Amphiphiles and their anti-HIV-1 Activity”, Carbohydrate Research, vol. 327, Issue 3, Jul. 24, 2000, pp. 223-260.
A. Sasaki et al., “Syntheses of Novel Galactosyl Ligands for Liposomes and the Influence of the Spacer on Accumulation in the Rat Liver”, Biological & Pharmaceutical Bulletin, vol. 18, No. 5. May 5, 1995, pp. 740-746.
Hara, M. et al., “Galactocerebroside and Not Glucocerebroside or Ceramide Stimulate Epidermal β-Glucocerebrosidase Activity,” Journal of Dermatological Science, Jan. 1998, vol. 16, No. 2, pp. 111-119.

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