Galactoside inhibitors of galectins

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C514S053000

Reexamination Certificate

active

07638623

ABSTRACT:
The present invention relates to novel compounds and the use of said compounds as a medicament, as well as for the manufacture of a medicament for treatment of disorders relating to the binding of galectin to receptors in a mammal. Said galectin is preferably galectin-3.

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Helland et al., “Methyl 3-amino-3deoxy-B-D-galactopyranosyl-(1-4)-2-acetamido-20deoxy-B-D-glucopyranoside: an inhibitor of UDP-D-galactose: B-D-galactopyranosyl-(1-4)-2 acetamido-2-deoxy-D-glucose (1-3) a-D-galactopyranosyltransferase” Carbohydrate Research 276 (1995) pp. 91-98.
Schwartz et al., “Thermodynamics of bovine Spleen Galectin-1 Binding to Disacchrides: Correlation with Structure and Its Effect on Oligomerization at the Denaturation Temperature” Biochemistry, 1998, 37, pp. 5867-5877.
Bachhawat-Sikder et al., “Thermodynamic analysis of the binding of galactose and poly-N-acetyllactosamine derivatives to human gallectin-3” Federation of European Biochemical Societies Letters, 500 (2001), pp. 75-79.
Oberg et al., “Efficient and Expedient Two-Step Pyranose-Retaining Fluorescein Conjugation of Complex Reducing Oligosaccharides: Galectin Oligosaccharide Specificity Studies in Fluorescence Polarization” Bioconjugate Chem. 2003, 14, 2003 American Chemical Society, pp. 1289-1297.
Sorme et al., “Low Micromoler Inhibitors of Galectin-3 Based on 3′-Derivatization of N-Acetyllactosamine” ChemBioChem, 2002, 3, pp. 183-189.

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