Galactose-C-6 nitrogen mustard compounds and their uses

Details Galactose-C-6 nitrogen mustard compounds and their uses Galactose-C-6 nitrogen mustard compounds and their uses

1984-10-31

1987-04-07

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 514 53, 536 41, 536 171, 536 172, 536 187, 536117, 536118, 536122, A61K 3170, C07H 506

Patent

active

046561595

ABSTRACT:
Compounds of the formula ##STR1## wherein X is halogen; each R independently represents H, a C.sub.1 -C.sub.4 alkyl group, a C.sub.2 -C.sub.4 alkanoyl group, a phosphate group, or a sulfate, sulfonate, or benzoate group with the proviso that no more than one sulfate, sulfonate, or benzoate group is present in said compound; and R' represents R or a carbohydrate residue derived from a carbohydrate having the formula R'OH with the proviso that R' and the R on C-2 or both R groups on C-3 and C-4 together can represent an isopropylidene group; or a pharmaceutically acceptable salt thereof, are disclosed along with methods of synthesizing and using these compounds.

REFERENCES:
patent: 2715123 (1955-08-01), Hodge
patent: 3005750 (1961-10-01), Fluck et al.
Wampler et al. Can. Res. 35, 1903-1906 (1975).
Reist et al., J. Amer. Chem. Soc., 82, 2025-2029 (1960).
Vargha et al., J. Chem. Soc., 1957, 810-812.

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