Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-06-02
1997-08-05
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
4351721, 43525233, 4353201, 536 235, 935 22, 935 23, 935 73, C12P 2106, C12N 1500, C12N 120, C07H 2104
Patent
active
056541724
ABSTRACT:
Disclosed is a human GABA.sub.A epsilon subunit receptor and DNA (RNA) encoding such polypeptides (RNA). Also provided is a procedure for producing such polypeptides by recombinant techniques and agonists and antagonists for such polypeptides. Also provided are methods of using the agonists, for example, to treat anxiety, Huntington's Chorea, muscular spasms and rigidity, and sleep and seizure disorders. Antagonists may be used, for example, to diagnose and treat anxiety, Huntington's Chorea, sleep and seizure disorders, Alzheimer's disease, Parkinson's disease and overdoses with benzodiazepine and for enhancing cognition and reversing sedation after application of general anesthesia during surgery. Also disclosed are diagnostic methods for detecting mutations in the polynucleotides of the present invention and for detecting levels of the soluble polypeptides in samples derived from a host.
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Kirkness Ewen F.
Li Yi
Fleisher Mindy
Human Genome Sciences Inc.
Mullins J. G.
Olstein Elliot M.
Weiss Bonnie D.
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