GABA and L-glutamic acid analogs for antiseizure treatment

Details GABA and L-glutamic acid analogs for antiseizure treatment GABA and L-glutamic acid analogs for antiseizure treatment

1995-04-12

1997-02-04

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562507, 562553, 562571, C07C22900

Patent

active

055999735

ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are also disclosed.

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Colonge, Bull. Soc. Chim. Fr., pp. 598-603 (1962).
Andruszkiewicz, Synthesis, pp. 953-955 (1989, received by PTO Jan. 18, 1990).

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