GABA and L-glutamic acid analogs for antiseizure treatment

Details GABA and L-glutamic acid analogs for antiseizure treatment GABA and L-glutamic acid analogs for antiseizure treatment

1998-04-21

2000-02-22

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560179, C07C 6966

Patent

active

060282142

ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 is a straight or branched alkyl group having from 1 to 6 carbon atoms, phenyl, or cycloalkyl having from 3 to 6 carbon atoms; R.sub.2 is hydrogen or methyl; and R.sub.3 is hydrogen, methyl or carboxyl; which is useful in the treatment of seizure disorders. Processes are also disclosed for the preparation of the compound. Intermediates prepared during the synthesis of the compound are further disclosed.

REFERENCES:
patent: 4559361 (1985-12-01), Dickens
patent: 4996358 (1991-02-01), Handa
patent: 5256657 (1993-10-01), Singh
patent: 5304549 (1994-04-01), Broadhurst
patent: 5387610 (1995-02-01), Gray
patent: 5514677 (1996-05-01), Davidson

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