GABA A receptor epsilon subunits

Details GABA A receptor epsilon subunits GABA A receptor epsilon subunits

2008-04-29

2008-04-29

Landsman, Robert (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S402000, C435S069100, C435S471000

Reexamination Certificate

active

11346326

ABSTRACT:
The present invention relates to a novel GABAAreceptor ε subunit (GABRE) and an alternative transcript thereof (ET2). More specifically, isolated nucleic acid molecules are provided encoding human GABRE and ET2 receptor subunits. ET2 and GABRE polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of ET2 and GABRE activities. Also provided are diagnostic methods for detecting aberrant GABRE and ET2 expression, as well as therapeutic methods for treating disorders involving ET2 and GABRE.

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