Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-09
2006-05-09
Andres, Janet (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007210, C435S007800
Reexamination Certificate
active
07041457
ABSTRACT:
The invention provides a series of Gαqprotein variants that functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional coupling can be determined, for example, by measuring changes in intracellular IP3, or calcium. In a particular embodiment, the Gαqprotein variants can be expressed in mammalian cell lines orXenopusoocytes, and then evaluated using calcium fluorescence imaging and electrophysiological recording.
REFERENCES:
Strothmann et al.,PNAS, vol. 87, pp. 9113-9117, Dec. 1990.
Xu Hong
Yao Yong
Andres Janet
Duane Morris LLP
Gucker Stephen
Senomyx Inc.
Teskin Robin L.
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