G-protein fusion receptors and constructs encoding same

Details G-protein fusion receptors and constructs encoding same G-protein fusion receptors and constructs encoding same

2007-08-28

2007-08-28

Landsman, Robert S. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

C530S350000, C536S023400, C536S023500, C435S069100, C435S252300, C435S320100, C435S325000, C435S471000

Reexamination Certificate

active

09679664

ABSTRACT:
The present invention features G-protein fusion receptors and chimeric GABABreceptors (GABABRs), nucleic acid encoding such receptors, and the use of such receptors and nucleic acid. G-protein fusion receptors comprise at least one domain from a CaR, an mGluR, and/or a GABABreceptor fused directly or through a linker to a guanine nucleotide-binding protein (G-protein). Chimeric GABABRs comprise at least one of a GABABR extracellular domain, a GABABR transmembrane domain, or a GABABR intracellular domain and one or more domains from a mGluR subtype 8 (mGluR8) and/or a CaR.

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