G-protein coupled receptors

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C424S143100

Reexamination Certificate

active

07084259

ABSTRACT:
The invention provides isolated nucleic acid and amino acid sequences of four novel G-protein coupled receptors that are amplified in breast cancer cells, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of G-protein coupled receptors.

REFERENCES:
patent: WO 96/30406 (1996-10-01), None
patent: WO 01/27158 (2001-04-01), None
patent: WO 01/68805 (2001-09-01), None
Birren, B. et al. “Homo sapienschromosome 18, clone RP11-482N10” Database Genembl (Online) Accession AC023386, nucleotides 98850-993300 and nucleotides 75400-76070.
Buck, et al. “A Novel Multigene Family May Encode Odorant Receptors: A Molecular Basis for Odor Recognition”Cell(Apr. 1991) vol. 65, pp. 175-187.
Carmeci, et al. “Identification of a Gene (GPR30) with Homology to the G-Protein-Coupled Receptor Superfamily Associated with Estrogen Receptor Expression in Breast Cancer”Genomics(Nov. 1997) vol. 45(3); pp. 607-617.
Drutel, G. et al. “Cloning of OL1, A Putative Olfactory Receptor and Its Expression in the Developing Rat Heart”Receptors and Channels(1995) Vo. 3, pp. 33-40.
Mikayama, et al. “Molecular Cloning and Functional Expression of a cDNA Encoding Glycosylation-inhibition Factor”Proc. Natl. Acad.Sci USA(Nov. 1993) vol. 90, pp. 10056-10060.
Nef, et al. “Spatial Pattern of Receptor Expression in the Olfactory Epithelium”Proc. of Nat. Acad. Sci. USA(Oct. 1992) vol. 89; pp. 8948-8952.
Voet, et al. “Sickle-Cell Anemia: The Influence of Natural Selection”Biochemistry, 10th Ed. published by John Wiley&Sons, Inc. (1990), pp. 228-234.

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