G protein-coupled receptor protein, its DNA and ligand thereof

Details G protein-coupled receptor protein, its DNA and ligand thereof G protein-coupled receptor protein, its DNA and ligand thereof

2007-03-20

2007-03-20

Ulm, John (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C514S002600, C530S327000, C530S350000

Reexamination Certificate

active

10719587

ABSTRACT:
The polypeptides in the present invention possess the effects of promoting and inhibiting the secretion of prolactin, and are thus useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion stimulants, which are associated with the secretion of prolactin, such as hypoovarianism, spermatic underdevelopment, menopausal symptoms, hypothyroidism, etc. The polypeptides are useful as drugs for the prevention and treatment of various diseases, in terms of prolactin secretion inhibitors, which are associated with the secretion of prolactin, such as pituitary tumor, diencephalon tumor, menstrual disorder, autoimmune diseases, prolactinoma, sterility, impotence, amenorrhea, lactorrhea, acromegaly, Chiari-Frommel syndrome, Argonz-del Castilo syndrome, Forbes-Albright syndrome, lymphoma, Sheehan's syndrome, spermatogenesis disorder, etc.

REFERENCES:
Molecular Cloning and Chromosomal Localization of the Mouse Gpr37 Gene Encoding an Orphan G-Protein-Coupled Peptide Receptor Expressed in brain and Testis, Daniela Marazziti, et al., Genomics 53, 315-324 (1998) Article No. GE985433.
Dorland's Illustrated Medical Dictionary, 28thed. (1994).
The Merck Index, 13thed. (2001).
The Merck Manual, 17thed. (1999).
Concise Oxford English Dictionary (1990).

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