Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-04-24
2007-04-24
Ulm, John (Department: 1649)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S007210, C435S069100, C435S252300, C435S320100
Reexamination Certificate
active
10650467
ABSTRACT:
The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.
REFERENCES:
patent: 5585277 (1996-12-01), Bowie et al.
patent: 5859188 (1999-01-01), Geary et al.
patent: WO 97/09433 (1997-03-01), None
patent: WO 97/48976 (1997-12-01), None
TheC. elegansSequencing Consortium, Genome Sequence of the NematodeC. elegans: A Platform for Investigating Biology, Dec. 11, 1998, SCIENCE 282:2012-2018.
Gardner, A. NCBI accession No. T19340. Oct. 15, 1999.
Altschul, et al., “Gapped BLAST and PSI-BLAST: A New Generation of Protein Database Search Programs,”Nucl. Acids Res. 25:3389-3402 (1997).
Aujame, et al., “High-Affinity Human Antibodies by Phage Display,”Human Antibodies8:155-168 (1997).
Baindur, et al., “Selective Fluorescent Ligands for Pharmacological Receptors,”Drug Dev. Res. 33:373-398 (1994).
Bargmann, C., “Neurobiology of theCaenorhabditis elegansGenome,”Science282:2028-2032 (1998).
Birgul, et al., “Reverse phsyiology inDrosophila: Identification of a Novel Allatostatin-like Neuropeptide and its Cognate Receptor Structurally Related to the Mammalian Somatostatin/galanin/opioid Receptor Family,”EMBO Journal18:5892-5900 (1999).
Bohm, et al., “Regulatory Mechanisms That Modulate Signalling by G-protein-coupled Receptors,”Biochemistry Journal322:1-18 (1997).
Bosse, et al., “Development of Nonseparation Binding and Functional Assays for G Protein-Coupled Receptors for High Throughput Screening: Pharmacological Characterization of the Immobilized CCR5 Receptor on FlashPlate®,”J. Biomol. Screening3:285-292 (1998).
Boulton, et al., “ERKs: A Family of Protein-Serine/Threonine Kinases That Are Activated and Tyrosine Phosphorylated in Response to Insulin and NGF,”Cell65:663-675 (1991).
Bruggemann, et al., “Production of Human Antibody Repertoires in Transgenic Mice,”Current Opinions in Biotechnology8:455-458 (1997).
Bruggemann, et al., “Strategies for Expressing Human Antibody Repertoires in Transgenic Mice,”Immunol. Today17:391-397 (1996).
Cane, et al. , “Harnessing the Biosynthetic Code Combinations, Permutations, and Mutations,”Science282:63-68 (1998).
Cobbold, et al., “Aequorin Measurements of Cytoplasmic Free Calcium,” in Cellular Calcium: A Practical Approach, (McCormack, et al., eds. Oxford, IRL Press 1991).
Cox, et al., “Cloning Characterization, and Expression of a G-Protein-Coupled Receptor fromLymnaea stagnalisand Identification of a Leucokinin-Like Peptide, PSFHSWSamide, as Its Endogenous Ligand,”J. Neurosci. 17:1197-1205 (1997).
Day, et al., “Parasitic Peptides! The Structure and Function of Neuropeptides in Parasitic Worms,”Peptides20:999-1019 (1999).
de Bono, et al., “Natural Variation in a Neuropeptide Y Receptor Homolog Modifies Social Behavior and Food Response inC. elegans,” Cell94:679-689 (1998).
Dooley, et al., Binding andIn VitroActivities of Peptides with High Affinity for the Nociceptin/Orphanin FQ Receptor, ORL1,J. Pharm.&Exp. Therap. 283:735-741 (1997).
Dunlop, et al., Characterization of 5-HT1AReceptor Functional Coupling in Cells Expressing the Human 5-HT1AReceptor as Assessed with the Cytosensor Microphysiometer,J. of Pharmacol. and Toxicol. Methods40:47-55 (1998).
Fields, et al., “A Novel Genetic System to Detect Protein-protein Interactions,”Nature340:245-246 (1989).
Fields, et al., “The Two-hybrid System: an Assay for Protein-protein Interactions,”Trends in Genetics10:286-292 (1994).
Frandsen, et al., “A Simple Ultrasensitive Method for the Assay of Cyclic AMP and Cyclic GMP in Tissues,”Life Sciences18:529-541 (1976).
Geary, et al., “Pharmacology of FMRFamide-Related Peptides in Helminths,”Annals N. Y. Acad. Sci. 897:212-227 (1999).
Geary , et al., “The Pharmacology of FMRFamide-related Neuropeptides in Nematodes: New Opportunities for Rational Anthelmintic Discovery?,”International Journal of Parasitology25:1273-1280 (1995).
George, et al., “Evaluation of a CRE-Directed Luciferase Reporter Gene Assay as an Alternative to Measuring cAMP Accumulation,”J. Biomol. Screening2:235-240 (1997).
Gerhardt, et al., “Functional Characteristics of Heterologously Expressed 5-HT Receptors,”Eur. J. Pharmacol. 334:1-23 (1997).
Guerrero, “Cloning of a cDNA from Stable Fly which Encodes a Protein with Homology to aDrosophilaReceptor for Tachykinin-like Peptides,” F.D.,Annals N.Y. Acad. Sci. 814:310-311 (1997).
Hill, “Trends in Development of High-throughput Screening Technologies for Rapid Discovery of Novel Drugs,”Curr. Opin. In Drug Disc.&Dev. 1:92-97 (1998).
Hodgson, “Receptor Screening and the Search for New Pharmaceuticals,”Bio/Technology10:973-980 (1992).
Holmes, et al., “Cloning and Transcriptional Expression of a Leucokinin-like Peptide Receptor from the Southern Cattle Tick,Boophilus microplus( Acari: Ixodidae),”Insect Mol. Biol. (2000 in press).
Hoogenboom, “Designing and Optimizing Library Selection Strategies for Generating High-affinity Antibodies,”TIBTECH15:62-70 (1997).
Jaquette, et al., “Temperature Sensitivity of Some Mutants of Lutropin/Choriogonadotropin Receptor,”Endocrinology138:85-91 (1997).
Jayawickreme, et al., “Gene Expression Systems in the Development of High-throughput Screens,”Current Opinion in Biotechnology8:629-634 (1997).
Kanterman, et al., “Transfected D2Dopamine Receptors Mediate the Potentiation of Arachidonic Acid Release in Chinese Hamster Ovary Cells,”Molecular Pharmacology39:364-369 (1991).
Kowal, et al., “A [35S]GTPγS Binding Assessment of Metabotropic Glutamate Receptor Standards in Chinese Hamster Ovary Cell Lines Expressing the Human Metabotropic Receptor Subtypes 2 and 4,”Neuropharmacology37:179-187 (1998).
Kozak, et al., “An Analysis of 5′-noncoding Sequences from 699 Vertebrate Messenger RNAs,”Nucl. Acids Res. 15:8125-8148 (1987).
Kuntzweiler, et al., “Rapid Assessment of Ligand Actions with Nicotinic Acetylcholine Receptors Using Calcium Dynamics and FLIPR,”Drug Development Research44:14-20 (1998).
Lajiness, et al., “D2 Dopamine Receptor Stimulation of Mitogenesis in Transfected Chinese Hamster Ovary Cells: Relationship to Dopamine Stimulation of Tyrosine Phosphorylations,”Journal of Pharmacology and Experimental Therapeutics267:1573-1581 (1993).
Lenz, et al., “Molecular Cloning and Genomic Organization of a Novel Receptor fromDrosophila melanogasterStructurally Related to Mammalian Galanin Receptors,”Biochem. Biophys. Res. Comm. 269:91-96 (2000).
Li, et al., “Neuropeptide Gene Families in the NematodeCaenorhabditis elegans,” Annals N. Y. Acad. Sci. 897:239-252 (1999).
Li, et al., “Cloning, Functional Expression, and Developmental Regulation of a Neuropeptide Y Receptor fromDrosophila melanogaster,” J. Biol. Chem. 267:9-12 (1992).
Myers, P.L., “Will Combinatorial Chemistry Deliver Real Medicines?,”Current Opinion in Biotechnology8:701-707 (1997).
Nakayama, et al., “Microplate Assays for High-Throughput Screening,”Drug Disc.&Dev. 1:85-91 (1998).
Pausch, M.H., “G-protein-coupled Receptors inSaccharomyces cerevisiae: High-throughput Screening Assays for Drug Discovery,”Trends in Biotech. 15:487-494 (1997).
Radar, et al., “Phage Display of Combinatorial Antibody Libraries,”Current Opinions in Biotechnology8:503-508 (1997).
Rogers, “Light on High
Geary Timothy G.
Kubiak Teresa M.
Larsen Martha J.
Lowery David E.
Pharmacia & Upjohn Company
Pharmacia & Upjohn Company
Ulm John
Wooton Thomas A.
LandOfFree
G protein-coupled receptor-like receptors and modulators... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with G protein-coupled receptor-like receptors and modulators..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and G protein-coupled receptor-like receptors and modulators... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3764364