G-protein coupled receptor ligands and methods

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007100, C435S007200, C436S501000

Reexamination Certificate

active

07807390

ABSTRACT:
The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention also relates to methods for modulating a G-protein coupled receptor and for identifying substances which modulate the receptor.

REFERENCES:
patent: 6927041 (2005-08-01), Zhelnin et al.
patent: 2003/0223992 (2003-12-01), Jiang et al.
patent: 2004/0248790 (2004-12-01), Hinuma et al.
patent: 1207201 (2002-05-01), None
patent: WO97/37967 (1997-10-01), None
patent: WO99/32519 (1999-07-01), None
patent: WO 00/11015 (2000-03-01), None
patent: WO 00/22131 (2000-04-01), None
patent: WO 00/31258 (2000-06-01), None
patent: WO00/66151 (2000-11-01), None
patent: WO 00/78809 (2000-12-01), None
patent: WO 01/16316 (2001-03-01), None
patent: WO 01/48189 (2001-07-01), None
Liu et al., “Identification and Characterization of Novel Mammalian Neuropeptide FF-like Peptides that Attenuate Morphine-induced Antinociception”; J. Biol. Chem. (2001) 276(40):36961-36969.
Li et al., “FMRFamide-relatedneuropeptide gene family in Caenorhabditis elegans”; Brain Research (1999) 848:26-34.
Takayasu et al., A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc Natl Acad Sci U S A. May 9, 2006;103(19):7438-43.
Chartrel et al., Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc. Natl. Acad. Sci. U S A. Dec. 9, 2003;100(25):15247-52.
Chartrel et al., Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals. Ann. N.Y. Acad. Sci. Apr. 2005;1040:80-3.
Moriya et al., RFamide peptide QRFP43 causes obesity with hyperphagia and reduced thermogenesis in mice. Endocrinology. Jun. 2006;147(6):2916-22.
Lee et al., Discovery and mapping of ten novel G protein-coupled receptor genes. Gene (2001) 275: 83-91.
Bowie et al., Deciphering the message in protein sequences: tolerance to amino acid substitutions, Science. 1990 247(4948):1306-10.
Guo et al., Protein tolerance to random amino acid change, Proc Natl Acad Sci U S A. Jun. 22, 2004;101(25):9205-10. Epub Jun. 14, 2004.
Jiang et al., Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155, J Biol Chem. Jul. 25, 2003;278(30):27652-7.
Jiang et al., Identification and characterization of a novel peptide ligand for orphan G-protein coupled receptor SP9155, Biopolymers (2003) 71(3): 296.
Nagai et al., Cooling sensitive [Ca2+]i response associated with signaling of G protein-coupled receptors, Biochem Biophys Res Commun. Jul. 30, 1998;248(3):733-7.
Fukusumi et al., A new peptidic ligand and its receptor regulating adrenal function in rats, J Biol Chem. Nov. 21, 2003;278(47):46387-95.
Jiang, Ying, et al., PepPat, a pattern-based oligopeptide homology search method and the identification of a novel tachykinin-like peptide. Mammalian Genome (2003) 14:341-349.
Klein, Robert F., et al., Confirmation and Fine Mapping of Chromosomal Regions Influencing Peak Bone Mass in Mice. J. Bone Min. Res. (2001) 16(11):1953-1961.
Benes, Helen, et al., Chromosomal Mapping of Osteopenia-Associated Quantitative Trait Loci Using Closely Related Mouse Strains. J. Bone Min. Res (2000) 15(4):626-633.
Joost, Patrick, et al., Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands. Genome Biology 2002, 3(11):research0063.1-0063.16.
Sequence Disclosure-Genbank Accession No. BB200502 (created: Jun. 30, 2000; last updated Aug. 31, 2001).
Sequence Disclosure-Genbank Accession No. BB634210 (Aug. 31, 2001).
Sequence Disclosure-Genbank Accession No. BB613620 (Aug. 31, 2001).
Sequence Disclosure-Genbank Accession No. XM—071001 (Aug. 1, 2002).
Sequence Disclosure-Genbank Accession No. AL161733 (Dec. 3, 2001).
Sequence Disclosure-Genbank Accession No. BF167714 (created Oct. 27, 2000; last updated Oct. 30, 2000).
International Search Report for International Application No. PCT/US03/11159 (completed Sep. 20, 2004; mailed Dec. 7, 2004).
Ensembl genome database entry, SP9155 (Oct. 2006).
Do Rego et al., Behavioral effects of 26RFamide and related peptides. Peptides. Nov. 2006;27(11):2715-21. Epub May 30, 2006.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

G-protein coupled receptor ligands and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with G-protein coupled receptor ligands and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and G-protein coupled receptor ligands and methods will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4171173

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.