G-protein coupled receptor HUVCT36

Details G-protein coupled receptor HUVCT36 G-protein coupled receptor HUVCT36

1996-10-03

1999-06-15

Ulm, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4352523, 4353201, 530350, C12N 1512, C07K 14705

Patent

active

059123354

ABSTRACT:
Human HUVCT36 polypeptides and DNA (RNA) encoding such HUVCT36 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HUVCT36 for the treatment of infections, such as bacterial, fungal, protozoan and viral infections, particularly infection caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HUVCT36 and for detecting altered levels of the polypeptide in a host.

REFERENCES:
An, S., Tsai, C., Goetzl, E.J., "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue", FEBS Letters, 1995, 375:121-125.
An, S., GenBank Submission, Accession No. U35398, "Human G protein-coupled receptor mRNA, complete cds."
Heiber, M., et al., "Isolation of Three Novel Human Genes Encoding G Protein-Coupled Receptors", DNA and Cell Biology, 1995, 14(1):25-35.
Ye, R.D., Prossnitz, E.R., Zou, A. and Cochrane, C.G., "Characterization of a Human cDNA that Encodes a Functional Receptor for Platelet Activating Factor", Biochemical and Biophysical Research Communications, 1991, 180(1):105-111.
Ngo et al. In: The Protein Folding Problem and Tertiary Structure Prediction.1994, Merz et al. (ed.) Birkhauser, Boston, MA pp. 433, 492-495.
Songzhu et al. 1995 FEBS Letters 375: 121-124.
Mahadevan et al. 1995 Genomics 30: 84-88.
Heiber et al. 1995 DNA and Cell Biol. 14:25-35.
George et al. "Current Methods in Sequence Comparison and Analysis". Macromolecular Sequencing and Synthesis, Selected Methods an Applications. pp. 127-149, Jul. 1988.

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