Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1996-10-08
1998-11-10
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530325, 530326, 530350, 514 2, C07K 14705
Patent
active
058345876
ABSTRACT:
Human HLTEX11 polypeptides and DNA (RNA) encoding such HLTEX11 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HLTEX11 for the treatment of atherosclerosis, inflammatory conditions, and infections, particularly viral infections, such as AIDS, among others, among others, are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HLTEX11 and for detecting altered levels of the polypeptide in a host.
REFERENCES:
Nakamura, M., et al., Molecular Cloning and Expression of Platelet-Activating Factor Receptor from Human Leukocytes, J. Biol. Chem., 1991, 266(30):20400-20405.
Kaplan, M.H. et al., Identification of a G Protein Coupled Receptor Induced in Activated T Cells, J. Immun., 1993, 151:628-636.
McKernan et al. Heterogeneity Between Soluble Human and Rabbit Splenic alpha2-Adrenoceptors. Biochemical Pharmacology 35(20):3517-3523, Oct. 15, 1986.
Bergsma Derk J.
Chan Winnie
Ellis Catherine E.
Han William T.
King William T.
Prestia Paul F.
SmithKline Beecham Corporation
Ulm John
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