Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-03-08
2005-03-08
Spector, Lorraine (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000, C530S300000, C552S540000, C514S012200, C435S007100, C435S069100
Reexamination Certificate
active
06864229
ABSTRACT:
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
REFERENCES:
patent: 5747267 (1998-05-01), Mulvihill et al.
patent: 5925549 (1999-07-01), Hsueh et al.
patent: 6096868 (2000-08-01), Halsey et al.
patent: 6111076 (2000-08-01), Fukusumi et al.
patent: 6162808 (2000-12-01), Kindon et al.
patent: WO 9800538 (1998-01-01), None
patent: WO 9834948 (1998-08-01), None
patent: WO 9943711 (1999-09-01), None
patent: WO 9962494 (1999-12-01), None
Coughlin, et al, 2003, J. Clin. Invest., 111(1): 25-27.*
Covic, et al. (2002). “Activation and inhibition of G protein-coupled receptors by cell-penetrating membrane-tethered peptides”Proc Natl Acad Sci USA99(2): 643-648.
Covic, et al. (2000). “Intracellular liganding of the PAR1 thrombin receptor by a novel class of cell penetrating peptides”Blood96(11): 244a. Abstract #1050.
Faruqi, et al. (2000). “Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides”J. Biol. Chem.275(26): 19728-19734.
Hammes and Coughlin (1999). “Protease-Activated Receptor-1 Can Mediate Responses to SFLLRN in Thrombin-Desensitized Cells: Evidence for a Novel Mechanism for Preventing or Terminating Signaling by PAR1's Tethered Ligand”Biochem.38: 2486-2493.
Moro, et al. (1993). “Hydrophobic Amino Acid in the i2 Loop Plays a Key Role in Receptor-G Protein Coupling”J. Biol. Chem.268(30): 22273-22276.
Swift, et al. (2000). “PAR1 Thrombin Receptor-G Protein Interactions”J. Biol. Chem.275(4): 2627-2635.
Trejo and Coughlin (1999). “The Cytoplasmic Tails of Protease-activated Receptor-1 and Substance P Receptor Specify Sorting to Lysosomes versus Recycling”J. Biol. Chem.274(4): 2216-2224.
International Search Report for PCT/US01/13063. Mailed on Apr. 9, 2002.
Elliot, J. T., Prestwich, G. D. (2000) Maleimide-Functionalized Lipids that Anchor Polypeptides to Lipid Bilayers and Membranes.Bioconjugate Chemistry11(6):832-841.
Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le Trong, I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., Miyano, M. (2000) Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor.Science289:739-745.
Gether, U., Kobilka, B. K. (1998) G Protein-coupled Receptors.J. Biol. Chemistry273:17979-17982.
Cotecchia, S., Ostrowski, J., Kjelsberg, M. A., Caron, M. G., Lefkowitz, R. J. (1992) Discrete Amino Acid Sequences of the α1-Adrenergic Receptor Determine the Selectivity of Coupling to Phosphatidylinositol Hydrolysis.J Biol. Chemistry267:1633-1639.
Kostenis E., Conklin, B. R., Wess, J. (1997) Molecular Basis of Receptor/G Protein Coupling Sensitivity Studies by Coexpression of Wild Type and Mutant m2 Muscarinic Receptors with Mutant GαqSubunits.Biochemistry36:1487-1495.
Kjelsberg, M. A., Cotecchia, S., Ostrowski, J., Caron, M. G., Lefkowitz, R. J. (1992) Constiutive Activator of the α1B-Adrenergic Receptor by All Amino Acid Substitutions at a Single Site.J Biol. Chemistry267:1430-1433.
Luttrell, L. M., Ostrowski, J., Cotecchia, S., Kendall, H., Lefkowitz, R. J. (1993) Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors.Science259:1453-1457.
Okamoto T., Murayama, Y., Hayashi, Y., Inagaki, M., Ogata, E., Nishimoto, I. (1991) Identification of a GSActivator Region of the β2-Adrenergic Receptor That is Autoregulated via Protein Kinase A-Dependent Phosphorylation.Cell67:723-730.
Gilman, A. G. (1987) G Proteins: Transducers of Receptor-Generated Signals.Ann. Rev. Biochem.56:615-649.
Higashijima, T., Uzu, S., Nakajima, T., Ross, E. M. (1988) Mastoparan, a Peptide Toxin from Wasp Venom, Mimics Receptors by Activating GTP-binding Regulatory Proteins (G Proteins).J Biol. Chemistry263:6491-6494.
Bernatowicz, M. S., Klimas, C. E., Hartl, K. S., Peluso, M., Allegretto, N. J., Seiler, S. M. (1996) Development of Potent Thrombin Receptor Antagonist Peptides.J. Med. Chem.39:4879-4887.
Kuliopulos, A., Covic, L., Seeley, S., Sheridan, P. J., Helin, J., Costello, C. E. (1999) Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy.Biochemistry38:4572-4585.
Rojas, M., Donahue, J. P., Tan, Z., Lin, Y. (1998) Genetic Engineering of Proteins with Cell Membrane Permeability.Nature Biotechnology16:370-375.
Schwarze, S. R., Ho, A., Vocero-Akbani, A., Dowdy, S. F. (1999) In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse.Science285:1569-1572.
Wikstrom, P., Kirschke, H., Stone, S., Shaw, E. (1989) The Properties of Peptidyl Diazoethanes and Chloroethanes as Protease Inactivators.Archives of Biochem.&Biophysics270:286-293.
Stephens, G., O'Luanaigh, N., Reilly, D., Harriott, P., Walker, B., Fitzgerald, D., Moran, N. (1998) A Sequence within the Cytoplasmic Tail of GpIIb Independently Activates Platlet Aggregation and Thromboxane Synthesis.J Biol. Chemistry273:20317-20322.
Nystedt, S., Emilsson, K., Wahlestedt, C., Sundelin, J. (1994) Molecular Cloning of a Potential Proteinase Activated Receptor.Proc. Natl. Acad. Sci.91:9208-9212.
Xu, W., Andersen, H., Whitmore, T. E., Presnell, S. R., Yee, D. P., Ching, A., Gilbert, T., Davie, E. W., Foster, D. C. (1998) Cloning and Characterization of Human Protease-Activated Receptor 4.Proc. Natl. Acad. Sci.95:6642-6646.
Kahn, M. L., Zheng, Y., Huang, W., Bigornia, V., Zeng, D., Moff, S., Farese, R. V., Tam, C., Couglin, S. R. (1998) A Dual Thrombin Receptor System for Platelet Activation.Nature394:690-694.
Covic, L., Gresser, A. L., Kuliopulos, A. (2000) Biphasic Kinetics of Activation and Signaling for PAR1 and PAR4 Thrombin Receptors in Platelets.Biochemistry39:5458-5467.
Oosterom, J., Garner, K. M., den Dekker, W. K., Nijenhuis, W. A. J., Hendrick, Gispen, W. H., Burbach, J. P. H., Barsh, G. S., Adan, R. A. H. (2001) Common Structure for Melanocortin-4 Receptor Selectivity of Structurally Unrelated Melanocortin Agonist and Endogenous Antagonist, Agouti Protein.J Biol. Chemistry276:931-936.
Milligan, G. (2000) Receptors as Kissing Cousins.Science288:65-67.
Pfeiffer, M., Koch, T., Schröder, Klutzny, M., Kirscht, S., Kreienkamp, H., Höllt, V., Schulz, S. (2001) Homo- and Heterodimerization of Somatostatin Receptor Subtypes.J Biol. Chemistry276:14027-14036.
Ishii et al. (1994).J. Biol. Chem.269:1125-1130.
Tarasova, Nadya (1999). “Inhibition of G-Protein-coupled Receptor Function by Disruption of Transmembrane Domain Interactions”J. Biol. Chem.274:34911-34915.
Vergnolle, et al. “Protease-Activated Receptors in Inflammation, Neuronal Signaling and Pain”TRENDS Pharma. Sci.22:146-152.
Andrade-Gordon, et al., “Design, Synthesis, and Biological Characterization of a Peptide-Mimetic Antagonist for a Tethered-Ligand Receptor”,Proc. Natl. Acad. Sci. USA,96(22):12257-12262 (1999).
George, et al., “A Transmembrane Domain-Derived Peptide Inhibits DI Dopamine Receptor Function without Affecting Receptor Oligomerization”,J. Biol. Chem.,273(46):30244-30248 (1998).
Ishii, et al., “Determinants of Thrombin Receptor Cleavage”,J. Biol. Chem.,270(27):16435-16440 (1995).
Covic Lidija
Kuliopulos Athan
Beattie Ingrid A.
New England Medical Center Hospitals Inc.
Spector Lorraine
Triano, III Nicholas P.
Wegert Sandra
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