G protein-coupled receptor, GAVE10

Details G protein-coupled receptor, GAVE10 G protein-coupled receptor, GAVE10

2002-09-30

2008-10-07

Bertoglio, Valarie (Department: 1632)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024300, C536S024310

Reexamination Certificate

active

07432361

ABSTRACT:
Novel GPCR GAVE10 polypeptides, proteins and nucleic acid molecules are provided. GAVE10, recombinant expression vectors, host cells incorporating GAVE10 expression vectors and non-human transgenic animals into which a GAVE10 gene has been introduced or disrupted are taught. Diagnostic, screening and therapeutic methods utilizing compositions of the invention also are provided.

REFERENCES:
patent: 2002/0119493 (2002-08-01), Glucksmann
patent: 1 270 724 (2003-01-01), None
patent: 1 273 659 (2003-01-01), None
patent: 1 347 052 (2003-09-01), None
patent: WO 02/10387 (2002-02-01), None
GenBank Acc. No. AF275151, Chan, M.T.W., Rattus norvegicu androgen receptor-related apoptosis-associate protein CBL27 mRNA, Jul. 20, 2000, US National Library of Medicine, Bethesda, MD, accessed by PTO on Oct. 4, 2006.
Alignment of Genbank Accession No. AF275151 (nucleotides 1-25) with nucleotides 73-97 of SEQ ID No. 1.
Kennel, D. 1971, Principles and practices of nucleic acid hybridiaqtion, Prog Nucl Acid Res Mol Biol 11:259-301.
GenBank Acc. No. J04617, Uetski, T, Human elongation factor EF-1-alpha gene, Nov. 7, 1994, US National Library of Medicine, Bethesda, MD, accessed by PTO on Oct. 4, 2006.
Alignment of Genbank Accession No. J04617 (nucleotides 1522-1563) with nucleotides 9-49 of SEQ ID No. 1.
Kremer, L et al., 1999, In vivo immunomodulation folloeing intradermal injection with DNA encoding IL18, Jour Immunol., 163:3226-3231.
Alignment of Genbank Accession No. AX375233 (SEQ ID No. 23 of WO0210387) with SEQ ID No. 1.
Alignment of SEQ ID No. 3 of US2002/0119493A1 with SEQ ID No. 2 of the instant application.
U.S. Appl. No. 09/911,005, filed Jul. 23, 2001, Glucksmann.
Chen, Grace et al., Use of Constitutive G Protein-Coupled Receptor Activity for Drug Discovery, Molecular Pharmacology, (2000), vol. 57, pp. 125-134.
Pauwels, Petrus J. et al., Review: Aminio Acid Domains Involved in Constitutive Activation of G-Protein-Coupled Receptors, Molecular Neurobiology, (1998), vol. 17, pp. 109-135.
Takeda, Shegeki et al., Systematic search for G protein-coupled receptor genes from human genome database.

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