G-protein coupled receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

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C514S002600

Reexamination Certificate

active

10890407

ABSTRACT:
The present invention is directed to a novel neurotensin-like receptor expressed in the central nervous system of humans. The invention encompasses the receptor protein as well as nucleic acids encoding the protein. In addition, the invention is directed to methods and compositions which utilize the receptor.

REFERENCES:
patent: WO 94/29447 (1994-12-01), None
Eva, et al., “Molecular Cloning of a Novel G Protein-Coupled Receptor that May Belong to the Neuropeptide Receptor Family,”FEBS Lett. 271(1,2):81-84 (1990).
Fluhmann, et al., “A Human Orphan Calcitonin Receptor-Like Structure,”Biochem. Biophys. Res. Comm. 206(1):341-347 (1995).
Gantz, et al., “Cloning and Chromosomal Localization of a Gene (GPR18) Encoding a Novel Seven Transmembrane Receptor Highly Expressed in Spleen and Testes,”Genomics 42(3):462-466 (1997).
Hillier, et al., “The WashU-Merck EST Project,” Database GenBank/DDBJ abstract, accession No. N45474.
Hosoya, et al., “Identification and Functional Characterization of a Novel Subtype of Neuromedin U Receptor,”J. Biol. Chem. 275(38):29528-29532 (2000).
McKee, et al., “Cloning and Characterization of Two Human G Protein-Coupled Receptor Genes (GPR38 and GPR39) Related to the Growth Hormone Secretagogue and Neurotensin Receptors,”Genomics 46:426-434 (1997).
Ross, et al., “RTA, a Candidate G Protein-Coupled Receptor: Cloning, Sequencing, and Tissue Distribution,”Biochemistry 87:3052-3056 (1990).
Tyler, et al., “Evidence for Additional Neurotensin Receptor Subtypes: Neurotensin Analogs that Distinguish Between Neurotensin-Mediated Hypothermia and Antinociception,”Brain Res. 792:246-252 (1998).
Zhou, et al., “Molecular Cloning and Characterization of an Adenosine Receptor: The A3 Adenosine Receptor,”P.N.A.S. 89:7432-7436 (1999).

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