G-CSF conjugates

Details G-CSF conjugates G-CSF conjugates

2006-08-10

2009-06-23

Lucas, Zachariah (Department: 1648)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

C530S350000, C530S402000, C514S002600

Reexamination Certificate

active

07550565

ABSTRACT:
Polypeptide conjugates with G-CSF activity comprising a polypeptide having at least one introduced lysine residue and at least one removed lysine residue compared to the sequence of human G-CSF, and which are conjugated to 2-6 polyethylene glycol moieties. The conjugates have a low in vitro bioactivity, a long in vivo half-life, a reduced receptor-mediated clearance, and provide a more rapid stimulation of production of white blood cells and neutrophils than non-conjugated recombinant human G-CSF.

REFERENCES:
patent: 4810643 (1989-03-01), Souza
patent: 4833127 (1989-05-01), Ono et al.
patent: 4853871 (1989-08-01), Pantoliano et al.
patent: 4904584 (1990-02-01), Shaw
patent: 4908773 (1990-03-01), Pantoliano et al.
patent: 4999291 (1991-03-01), Souza
patent: 5023802 (1991-06-01), Fujita
patent: 5025388 (1991-06-01), Cramer et al.
patent: 5104651 (1992-04-01), Boone
patent: 5109119 (1992-04-01), Reichert et al.
patent: 5157736 (1992-10-01), Boyer et al.
patent: 5214132 (1993-05-01), Kuga et al.
patent: 5218092 (1993-06-01), Sasaki et al.
patent: 5265030 (1993-11-01), Skolnick et al.
patent: 5281698 (1994-01-01), Nitecki
patent: 5307287 (1994-04-01), Cramer et al.
patent: 5320840 (1994-06-01), Camble et al.
patent: 5349052 (1994-09-01), Delgado et al.
patent: 5362853 (1994-11-01), Kuga et al.
patent: 5386507 (1995-01-01), Teig et al.
patent: 5399345 (1995-03-01), Schumacher et al.
patent: 5416195 (1995-05-01), Camble et al.
patent: 5424963 (1995-06-01), Turner et al.
patent: 5436850 (1995-07-01), Eisenberg et al.
patent: 5448498 (1995-09-01), Namiki et al.
patent: 5476653 (1995-12-01), Pitt et al.
patent: 5555366 (1996-09-01), Teig et al.
patent: 5580755 (1996-12-01), Souza
patent: 5581476 (1996-12-01), Osslund
patent: 5582823 (1996-12-01), Souza
patent: 5589456 (1996-12-01), Smith et al.
patent: 5597562 (1997-01-01), Nomura et al.
patent: 5676941 (1997-10-01), Souza
patent: 5681720 (1997-10-01), Kuga et al.
patent: 5714581 (1998-02-01), Kuga et al.
patent: 5738849 (1998-04-01), Bauer et al.
patent: 5772992 (1998-06-01), Bauer et al.
patent: 5773581 (1998-06-01), Camble et al.
patent: 5790421 (1998-08-01), Osslund
patent: 5795968 (1998-08-01), Kuga et al.
patent: 5817486 (1998-10-01), Bauer et al.
patent: 5824778 (1998-10-01), Ishikawa et al.
patent: 5824784 (1998-10-01), Kinstler et al.
patent: 5830705 (1998-11-01), Souza
patent: 5840521 (1998-11-01), Barth
patent: 5858347 (1999-01-01), Bauer et al.
patent: 5880255 (1999-03-01), Delgado et al.
patent: 5883230 (1999-03-01), Schendel
patent: 5985263 (1999-11-01), Lee et al.
patent: 5985265 (1999-11-01), Kinstler et al.
patent: 5997860 (1999-12-01), Bauer et al.
patent: 6004548 (1999-12-01), Souza
patent: 6017523 (2000-01-01), Bauer et al.
patent: 6022535 (2000-02-01), Bauer et al.
patent: 6027720 (2000-02-01), Kuga et al.
patent: 6030812 (2000-02-01), Bauer et al.
patent: 6051217 (2000-04-01), Bauer et al.
patent: 6057133 (2000-05-01), Bauer et al.
patent: 6060047 (2000-05-01), Bauer et al.
patent: 6066318 (2000-05-01), Feng
patent: 6074639 (2000-06-01), Bauer et al.
patent: 6093395 (2000-07-01), Bauer et al.
patent: 6100070 (2000-08-01), Zurfluh et al.
patent: 6132991 (2000-10-01), Bauer et al.
patent: 6153183 (2000-11-01), Bauer et al.
patent: 6166183 (2000-12-01), Ishikawa et al.
patent: 6204364 (2001-03-01), Todaro et al.
patent: 6261550 (2001-07-01), Osslund
patent: 6379661 (2002-04-01), Souza
patent: 6420339 (2002-07-01), Gegg
patent: 6555660 (2003-04-01), Nissen et al.
patent: 6632426 (2003-10-01), Osslund
patent: 6646110 (2003-11-01), Nissen et al.
patent: 6831158 (2004-12-01), Nissen et al.
patent: 7381804 (2008-06-01), Osslund
patent: 2002/0142964 (2002-10-01), Nissen et al.
patent: 2003/0204057 (2003-10-01), Ishikawa et al.
patent: 631312 (1992-11-01), None
patent: 641081 (1993-09-01), None
patent: 0243153 (1987-10-01), None
patent: 0 256 843 (1988-02-01), None
patent: 0272703 (1988-06-01), None
patent: 0 335 423 (1989-10-01), None
patent: 0 215 126 (1991-07-01), None
patent: 0 220 520 (1991-09-01), None
patent: 0459630 (1991-12-01), None
patent: 0473268 (1992-03-01), None
patent: 0490584 (1992-06-01), None
patent: 0502637 (1992-09-01), None
patent: 0 344 796 (1994-09-01), None
patent: 0 230 980 (1996-03-01), None
patent: 0401384 (1996-03-01), None
patent: 0 744 409 (1996-11-01), None
patent: 0 370 205 (1998-07-01), None
patent: 0733067 (1999-05-01), None
patent: 0 921 131 (1999-06-01), None
patent: 0 237 545 (1999-08-01), None
patent: 0 169 566 (2000-07-01), None
patent: 0 612 846 (2000-08-01), None
patent: 1 167 390 (2002-01-01), None
patent: 2213821 (1989-08-01), None
patent: 2246295 (1991-07-01), None
patent: 85/00817 (1985-02-01), None
patent: 88/01775 (1988-03-01), None
patent: WO 89/05824 (1989-06-01), None
patent: WO 89/10932 (1989-11-01), None
patent: WO 90/12874 (1990-11-01), None
patent: WO 91/05798 (1991-05-01), None
patent: 92/04455 (1992-03-01), None
patent: 9221029 (1992-11-01), None
patent: 9301484 (1993-01-01), None
patent: 93/25687 (1993-12-01), None
patent: WO 94/20069 (1994-09-01), None
patent: 95/20976 (1995-08-01), None
patent: 95/20977 (1995-08-01), None
patent: 95/21197 (1995-08-01), None
patent: 95/21254 (1995-08-01), None
patent: WO 95/21629 (1995-08-01), None
patent: 95/27732 (1995-10-01), None
patent: 87/01132 (1996-02-01), None
patent: WO 96/11953 (1996-04-01), None
patent: 96/23888 (1996-08-01), None
patent: 97/12978 (1997-04-01), None
patent: 97/12985 (1997-04-01), None
patent: WO 97/12977 (1997-04-01), None
patent: WO9711957 (1997-04-01), None
patent: 98/17810 (1998-04-01), None
patent: 98/18923 (1998-05-01), None
patent: 98/18924 (1998-05-01), None
patent: 98/46750 (1998-10-01), None
patent: WO 98/53072 (1998-11-01), None
patent: WO 99/03887 (1999-01-01), None
patent: WO 99/67291 (1999-12-01), None
patent: 00/18905 (2000-04-01), None
patent: WO 00/40728 (2000-07-01), None
patent: WO 00/44785 (2000-08-01), None
patent: WO 00/52057 (2000-09-01), None
patent: WO 01/04329 (2001-01-01), None
patent: WO 01/51510 (2001-07-01), None
patent: WO 02/20751 (2002-03-01), None
patent: WO 02/20766 (2002-03-01), None
patent: WO 02/20767 (2002-03-01), None
patent: WO 02/28896 (2002-04-01), None
Aritomi et al.,Nature401:713-717 (1999).
Bowen et al.,Experimental Hematology27: 425-432 (1999).
Hill et al.,Proc. Natl. Acad. Sci. USA90: 5167-5171 (1993).
Horan et al.,Biochemistry35(15): 4886-4896 (1996).
Nagata et al.,Nature319:415-418 (1986).
Riedhaar-Olson et al.,Biochemistry35: 9034-9041 (1996).
Satake-Ishikawa et al.,Cell Structure and Function17:157-160 (1992).
Souza et al.,Science232: 61-65 (1986).
Zink et al.,Biochemistry33: 8453-8463 (1994).
Yamasaki, M., et al., “Effect of Divalent Polyethylene Glycol Units, Conjugated on Human Granulocyte Colony-Stimulating Factor, on Biological Activities In Vitro and In Vivo,” Drugs Exptl. Clin. Res. 24(4):191-196 (1998).
Delgado, Cristine, et al., “The Uses and Properties of PEG-Linked Proteins”Critical Reviews in Therapeutic Drug Carrier Systems9 (3, 4): 249-304 (1992).
Young, Dennis C., et al., “Characterization of the receptor binding determinants of granulocyte colony stimulating factor”Protein Science(1997), 6:1228-1236.
Eliason J.F., et al. Extended activity in cynomolgus monkeys of a granulocyte colony-stimulating factor mutein conjugated with high molecular weight polyethylene glycol. Stem Cells, Jan. 2000, vol. 18, No. 1, 40-45.
Viens, P., et al., “Randomized, Controlled, Dose-Range Study of Ro 25-8315 Given Before and After a High-Dose Combination Chemotherapy Regimen in Patients with Metastatic or Recurrent Breast Cancer Patients,”J. Clinical Oncology, 20(1):24-36 (2002).
De Haan, G., et al.,British Journal of Haematology(2000) 110(3):638-646.
Abdel-Meguid et al., Three-dimensional structure of a genetically engineered variant of porcine growth hormone. PNAS 84:6434-6437 (1987).
Abrahmsen L, et al. Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution. Biochemistry 30(17):4151-4159 (1991).
Carter et al, Protein crystallization using incomplete factori

Affiliated with

Also associated with

Rating

G-CSF conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with G-CSF conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and G-CSF conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4118815