G-coupled receptor showing selective affinity for ATP

Details G-coupled receptor showing selective affinity for ATP G-coupled receptor showing selective affinity for ATP

2007-09-04

2007-09-04

Ulm, John (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C436S501000

Reexamination Certificate

active

10976678

ABSTRACT:
The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.

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Communi D. & Boeynaems J.M., Receptors responsive to extracellular pyrimidine nucleotides, Mar. 1997, TIPS, vol. 18, pp. 83-86.
Communi D. et al, Cloning of a Human Purinergic P2Y Receptor Coupled to Phospholipase C and Adenyl Cyclase, Dec. 1997, The Journal of Biological Chemistry, vol. 272 No. 51, pp. 31969-31973.
J.A. Parsons, M.A., B.M., B.Ch., Peptide Hormones, University Park Press, Jun. 1976.
Genbank Accession No. AA321112, Apr. 19, 1997.
Genbank Accession No. N34073, Jan. 11, 1996.
Hammer, et al., 1990, Spontaneous Inflammatory Disease in Transgenic Rats Expressing HLA-B27 and Human B2m: An Animal Model of HLA-B27-Associated Human Disorders, Nol. 30, 1990, Cell Press, vol. 63, 1099-1112.
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