FXR NR1H4 nuclear receptor binding compounds

Details FXR NR1H4 nuclear receptor binding compounds FXR NR1H4 nuclear receptor binding compounds

2006-08-29

2006-08-29

Balasubramanian, Venkataraman (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S332000, C514S275000

Reexamination Certificate

active

07098336

ABSTRACT:
The invention provides compounds according to the general formula (1) which bind to the NR1H4receptor and act as agonists, antagonists or mixed agonists/antagonists of the NR1H4receptor. The invention further provides methods of treating diseases and/or conditions through binding of the nuclear receptor by the compounds and the production of medicaments using the compounds.

REFERENCES:
patent: 5786355 (1998-07-01), Konno et al.
patent: 6051574 (2000-04-01), Anthony
patent: 6531479 (2003-03-01), Wang et al.
patent: 4237768 (1993-05-01), None
Bennett, Cecil Textbook of Medicine, 20th edition, vol. 1, 1004-1010, 1997.
Wilson et al. Med. Res. Rev. 21(6): 513-522, 2001.
Kast et al., Mol. Endocrinol., 15(10): 1720-1726, 2001.
Patil et al., Indian Journal of Heterocyclic Chemistry, 11(2): 132-134, 2001.
Bhat et al., Pharmacy and Pharmacology Communications, 6(12): 553-557, 2000.
Naik et al., Asian Journal of Chemistry, 12(4): 1373-1374, 2000.
Sharma et al., Indian Journal of Chemistry, 38B(8): 966-968, 1999.
Murthy et al., Indian Journal of Heterocyclic Chemistry, 8(4): 277-280, 1999.
Mehta et al., Asian Journal of Heterocyclic Chemistry, 10(4): 1017-1018, 1998.
Kadu et al., Research Journal of Chemistry and Environment, 2(1): 69-71, 1998.
Hussain et al., Asian Journal of Heterocyclic Chemistry, 9(1): 86-90, 1997.
Modi et al., Asian Journal of Heterocyclic Chemistry, 6(4): 1061-1062, 1997.
Modi et al., Asian Journal of Heterocyclic Chemistry, 6(4): 945-949, 1997.
Abdel-Halim et al., Indian Journal of Heterocyclic Chemistry, 3(3): 165-170, 1994.
Wendelin et al., Monatshefte fuer Chemie 115(3): 309-325, 1984.
Ankhiwala et al., Journal of Institution of Chemists (India), 62(3): 115-116, 1990.
Ankhiwala et al., Journal of Indian Chemical Society, 66(6): 417-418, 1989.
Thakar et al., Journal of Indian Chemical Society, 60(7): 671-673, 1983.
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48: 3-26, 2001.
“2-Amino-4,6-diarypyridines as Novel Ligands for the Estrogen Receptor.” Brad r. Henke et al.,Bioorganic&Medical Chemistry Letters 11(2001), pp. 1939-1942.
“Syntheses of 2-Alkylamino- and 2-Dialkylamino-4, 6-diarylpyridines and 2,4,6-Trisustituted Pyrimidines Using Solid-Phase-Bound Chalcones.” Alan R. Katritzky et al.,J. Comb. Chem.(2000), vol. 2, pp. 182-185.

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